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• Clinical Article •
A DTI study of brain white matter integrity in heroin addicts under short-time abstinence
YAN Xue-jiao  LI Wei  WANG Ya-rong  LI Qiang  LI Yong-bin  ZHU Jia  CHEN Jia-jie  WANG Wei 

DOI:10.3969/j.issn.1674-8034.2015.02.004.


[Abstract] Objective: To investigate the difference of brain white matter integrity between heroin addicts under short-time abstinence and control subjects by a diffusion tensor imagine(DTI)method, and explore the characteristics of changed brain white matter microstructure in heroin addicts under short-time abstinence.Materials and Methods: Twenty-five short-time abstinents and 20 control subjects were recruited. GE 3.0 T magnetic resonance scanner was used for DTI data acquisition. Tract-Based Spatial Statistics (TBSS) were used for fractional anisotropy (FA) comparison between HA group and HN group. Using two sample t test in SPSS 13.0 software to process demographic data, radial diffusivty (RD) value and axial diffusivty (AD) value between HA group and HN group. Partial correlation analysis was used between DTI indices and duration or dose of heroin use and duration of abstinence.Results: Compared with the HN group, significant reduced FA were found in several white matter regions including the genu of corpus callosum, the body of corpus callosum, bilateral anterior corona radiation, the left posterior corona radiata and the right of superior corona radiata in HA group. (P<0.01, corrected by TFEC and FWE) within these regions the HA group showed increased RD and decreased AD. (P<0.01) There were no regions showed significant increase. (P<0.01) There was no significant correlation between each DTI indices and duration or dose of heroin use and duration of abstinence. (P<0.05).Conclusions: White matter integrity significantly reduced in extensive regions among heroin addicts under short-time abstinence. the pathological features may include the abnormalities both in myelin and axonal. The involved brain areas mainly related to reward and cognitive controls. These findings may underline the high relapse rate in heroin addicts under short-time abstinence.
[Keywords] Heroin dependent；DTI；fMRI；Short-time abstinence；White matter

YAN Xue-jiao Department of Radiology, Tangdu Hospital, The Fourth Military Medical University, Shaanxi, xi’an, 710038, China

LI Wei Department of Radiology, Tangdu Hospital, The Fourth Military Medical University, Shaanxi, xi’an, 710038, China

WANG Ya-rong Department of Radiology, Tangdu Hospital, The Fourth Military Medical University, Shaanxi, xi’an, 710038, China

LI Qiang Department of Radiology, Tangdu Hospital, The Fourth Military Medical University, Shaanxi, xi’an, 710038, China

LI Yong-bin Department of Radiology, Tangdu Hospital, The Fourth Military Medical University, Shaanxi, xi’an, 710038, China

ZHU Jia Department of Radiology, Tangdu Hospital, The Fourth Military Medical University, Shaanxi, xi’an, 710038, China

CHEN Jia-jie Department of Radiology, Tangdu Hospital, The Fourth Military Medical University, Shaanxi, xi’an, 710038, China

WANG Wei* Department of Radiology, Tangdu Hospital, The Fourth Military Medical University, Shaanxi, xi’an, 710038, China

*Correspondence to: Wang W, E-mail: tdwangw@126.com

Conflicts of interest   None.

Received  2014-11-28
Accepted  2015-01-07
DOI: 10.3969/j.issn.1674-8034.2015.02.004
DOI:10.3969/j.issn.1674-8034.2015.02.004.

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