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• Clinical Article •
Study of structural asymmetry in language-related areas of the human cortex
ZUO Zhi-wei  QIAO Peng-gang  XING Xu-dong  WANG Xiang-chao  WANG Yi-tuo  LI Gong-jie 

DOI:10.3969/j.issn.1674-8034.2015.02.005.


[Abstract] Objective: This investigation analyzes the structural asymmetry in the human language-related cortex by means of structural magnetic resonance imaging.Materials and Methods: High-resolution three-dimensional T1 structural MRI scans were obtained from 60 participants. 5 regions of interest (ROIs) were selected: pars opercularis (POp), pars triangularis (PTr), anterior transverse temporal gyrus / Heschl's gyrus (HG), planum temporale (PT) and insula. A Freesurfer post processing pipeline was employed to perform surface reconstruction and measurements of cortical thickness (CT), cortical surface area (CSA) and cortical volume (CV). Differences between two sides of the anatomical measurements and laterality index (LI) of every ROI were analyzed. The correlation analysis was performed for the three measurements and their LI.Results: A right asymmetry in the HG and a leftward asymmetry in the insula was observed for CT. The POp, HG, PT, and insula were significantly leftward asymmetry for CV and CSA. No significant correlations between CT and CSA were found. The correlation between thickness asymmetry and volume asymmetry was not significant. Significant positive correlation exists between CSA asymmetry and CV asymmetry for all ROIs.Conclusions: The cortical architecture of language-related areas mainly showed a leftward asymmetry. CT and CSA were independent traits, and CV asymmetry was determined mostly by CSA asymmetry.
[Keywords] Magnetic resonance imaging；Language；Structural asymmetry

ZUO Zhi-wei Department of Radiology, 307 Hospital of PLA, Beijing, 100071, China

QIAO Peng-gang Department of Radiology, 307 Hospital of PLA, Beijing, 100071, China

XING Xu-dong Department of Radiology, 307 Hospital of PLA, Beijing, 100071, China

WANG Xiang-chao Department of Radiology, 307 Hospital of PLA, Beijing, 100071, China

WANG Yi-tuo Department of Radiology, 307 Hospital of PLA, Beijing, 100071, China

LI Gong-jie* Department of Radiology, 307 Hospital of PLA, Beijing, 100071, China

*Correspondence to: Li GJ, E-mail: ligj307@163.com

Conflicts of interest   None.

Received  2014-10-26
Accepted  2014-12-29
DOI: 10.3969/j.issn.1674-8034.2015.02.005
DOI:10.3969/j.issn.1674-8034.2015.02.005.

[1]
Toga A W, Thompson P M. Mapping brain asymmetry. Nature Reviews Neuroscience, 2003, 4(1): 37-48.
[2]
Altarelli I, Leroy F, Monzalvo K, et al. Planum temporale asymmetry in developmental dyslexia: revisiting an old question. Human brain mapping, 2014, 35(12): 5717-5735.
[3]
Fischl B, van der Kouwe A, Destrieux C, et al. Automatically parcellating the human cerebral cortex. Cerebral cortex, 2004, 14(1): 11-22.
[4]
Greve D N, Van der Haegen L, Cai Q, et al. A surface-based analysis of language lateralization and cortical asymmetry. Journal of cognitive neuroscience, 2013, 25(9): 1477-1492.
[5]
Keller S S, Roberts N, García-Fiñana M, et al. Can the language-dominant hemisphere be predicted by brain anatomy?. Journal of Cognitive Neuroscience, 2011, 23(8): 2013-2029.
[6]
张若成，李春艳，杨兵，等．创伤后应激障碍的记忆损害与脑结构MRI特点探讨．磁共振成像, 2013, 4(6): 416-419.
[7]
刘彩霞，鲍海华，李伟霞，等．慢性高原病患者脑灰质变化的VBM-MRI研究．磁共振成像, 2014, 5(3): 211-215.
[8]
Zhou D, Lebel C, Evans A, et al. Cortical thickness asymmetry from childhood to older adulthood. Neuroimage, 2013, 83: 66-74.
[9]
Dubois J, Benders M, Lazeyras F, et al. Structural asymmetries of perisylvian regions in the preterm newborn. Neuroimage, 2010, 52(1): 32-42.
[10]
Rakic P. Evolution of the neocortex: a perspective from developmental biology. Nature Reviews Neuroscience, 2009, 10(10): 724-735.
[11]
Hogstrom LJ, Westlye LT, Walhovd KB, et al. The structure of the cerebral cortex across adult life: age-related patterns of surface area, thickness, and gyrification. Cerebral Cortex, 2013, 23(11): 2521-2530.
[12]
Winkler AM, Kochunov P, Blangero J, et al. Cortical thickness or grey matter volume? The importance of selecting the phenotype for imaging genetics studies. Neuroimage, 2010, 53(3): 1135-1146.
[13]
Frye R E, Liederman J, Malmberg B, et al. Surface area accounts for the relation of gray matter volume to reading-related skills and history of dyslexia. Cerebral Cortex, 2010, 20(11): 2625-2635.
[14]
Rakic P. Specification of cerebral cortical areas. Science, 1988, 241(4862): 170-176.
[15]
Hill J, Inder T, Neil J, et al. Similar patterns of cortical expansion during human development and evolution. Proceedings of the National Academy of Sciences, 2010, 107(29): 13135-13140.

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