Share：
Share this content in WeChat
X
[Chinese][PDF]725177
• Clinical Article •
The value of quantitative dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) for differential diagnosis between malignant epithelial tumors and pleomorphic adenoma of lacrimal gland
CHEN Yue-jie  XIA Shuang  ZOU Yan-jun  ZHANG Ye  DING Ze 

DOI:10.3969/j.issn.1674-8034.2015.02.007.


[Abstract] Objective: To evaluate the value of dynamic contrast enhanced magnetic resonance imaging(DCE-MRI) for differential diagnosis between malignant epithelial tumor and pleomorphic adenoma of lacrimal gland.Materials and Methods: DCE-MRI data of 20 patients with pathologically confirmed malignant tumor and adenoma of lacrimal gland were retrospectively analyzed. Eight were benign and 12 were malignant. DCE-MRI was analyzed with the pharmacokinetic model proposed by Tofts and Kermode. There were three DCE quantitative parameters: Ktrans (volume transfer constant), Kep (rate constant) and Ve (extravascular extracellular space volume ratio). The dynamic curve was also analyzed. Z test was used to compare the different parameters between two groups.Chi-square test was used to analyze the difference of dynamic curves between groups. Receiver operating characteristic (ROC) curve was used to analyze the accuracy of parameters for differentiation of the two kinds of tumors.Results: Type of rapid washed in-platform was seen in 6 and 3 cases of pleomorphic adenoma and malignant tumor, respectively.Type of rapid washed inslowly washed out was seen in 2 and 9 cases of pleomorphic adenoma and malignant epithelial tumors. Value of Ktrans, Kep in malignant tumor were significantly higher than those of adenoma (Z=-2.533, -2.248, P<0.05). Ktrans is more sensitive than Kep to differentiate the pleomorphic adenoma and malignant epithelial tumors. When the cut off of Ktrans is 0.10, the sensitivity and specificity were 91.9% and 79.8%.Conclusions: Ktrans has a certain role in differential diagnosis for malignant epithelial tumor and pleomorphic adenoma of lacrimal gland.
[Keywords] Pleomorphic adenoma；Malignant epithelial tumor of lacrimal gland；DCE-MRI；Lacrimal gland

CHEN Yue-jie Imaging Center, Anshan Iron and Steel Group General Hospital, The 8th clinical hospital of China Medical University, Anshan 114002, China

XIA Shuang* Department of Radiology, First Central Hospital of Tianjin, Tianjin 300192, China

ZOU Yan-jun Imaging Center, Anshan Iron and Steel Group General Hospital, The 8th clinical hospital of China Medical University, Anshan 114002, China

ZHANG Ye Imaging Center, Anshan Iron and Steel Group General Hospital, The 8th clinical hospital of China Medical University, Anshan 114002, China

DING Ze Imaging Center, Anshan Iron and Steel Group General Hospital, The 8th clinical hospital of China Medical University, Anshan 114002, China

*Correspondence to: Xia S, E-mail: xiashuang77@163.com

Conflicts of interest   None.

Received  2014-11-11
Accepted  2015-01-15
DOI: 10.3969/j.issn.1674-8034.2015.02.007
DOI:10.3969/j.issn.1674-8034.2015.02.007.

[1]
张程芳，孙丰源，唐东润，等．泪腺上皮性肿瘤的特征及影像学分析．中国实用眼科杂志, 2013，31(8): 1064-1067.
[2]
白冬雪，孙夕林，王丹，等．动态对比增强MRI在鉴别胶质瘤复发及放射性损伤中的应用．磁共振成像, 2014, 5(1): 1-6.
[3]
李春媚，陈敏，李飒英，等. 3.0 T MR动态增强扫描定量分析诊断前列腺癌的初步研究．中华放射学杂志, 2011, 45(1): 50-54.
[4]
Lee Francis Kar-Ho, King Ann Dorothy, Ma Brigitte Buig-Yue, et al. Dynamic contrast enhancement magnetic resonance imaging (DCE-MRI) for differential diagnosis in head and neck cancers. Eur J Radiol, 2012, 81(4): 784-788.
[5]
Huang BS, Wong CS, Whitcher B, et al. Dynamic contrast-enhanced magnetic resonance imaging for characterizing nasopharyngeal carcinoma: comparison of semiquantitative and quantitative parameters and correlation with tumour stage. Eur Radiol, 2013, 23(6): 1495-1502.
[6]
Asaumi JI, Yanagi Y, Konouchi H, et al. Application of dynamic contrast-enhanced MRI to differentiate malignant lymphoma from squamous cell carcinoma in the head and neck. Oral Oncol, 2004, 40(6): 579-584.
[7]
Hisatomi M, Asaumi J, Yanagi Y, et al. Diagnostic value of dynamic contrast-enhanced MRI in the salivary gland tumors. Oral Oncol, 2007, 43(9): 940-947.
[8]
霍蕾,闫铄，王健，等．定量动态增强MRI对评价慢性期甲状腺相关眼病眼外肌受累的价值．磁共振成像, 2014, 5(1): 30-34.
[9]
Ishibashi H, Shiratuchi T, Nakagawa K, et al. Hypoxia-induced angiogenesis of cultured human salivary gland carcinoma cells enhances vascular endothelial growth factor production and basic fibroblast growth factor release. Oral Oncol, 2001, 37(1): 77-83.
[10]
Huang W, Li X, Morris EA, et al. The magnetic resonance shutter speed discriminates vascular properties of malignant and benign breast tumors in vivo. Proc Natl Acad Sci U S A, 2008, 105(46): 17943-17948.
[11]
da Cruz Perez DE, de Abreu Alves F, Nobuko Nishimoto I, et al. Prognostic factors in head and neck adenoid cystic carcinoma. Oral ncol, 2006, 42(2): 139-146.
[12]
陶晓峰，肖湘生，万卫平，等．动态增强MRI对眼眶海绵状血管瘤诊断及鉴别诊断的价值．中国医学计算机成像杂志, 2006, 12(3): 162-165.
[13]
何立岩，鲜军舫，王振常，等. MR及动态增强扫描诊断眼眶淋巴瘤的价值．中华放射学杂志, 2007, 41(9): 918-921.

PREV Analysis of the clinical and MRI characteristics in patient with acute transverse myelitis
NEXT Study of magnetic resonance imaging in the evaluation of left and right global function of patients with hypertrophic cardiomyopathy
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn