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• Clinical Article •
The value of quantitative dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) for differential diagnosis between malignant epithelial tumors and pleomorphic adenoma of lacrimal gland
CHEN Yue-jie  XIA Shuang  ZOU Yan-jun  ZHANG Ye  DING Ze 

DOI:10.3969/j.issn.1674-8034.2015.02.007.


[Abstract] Objective: To evaluate the value of dynamic contrast enhanced magnetic resonance imaging(DCE-MRI) for differential diagnosis between malignant epithelial tumor and pleomorphic adenoma of lacrimal gland.Materials and Methods: DCE-MRI data of 20 patients with pathologically confirmed malignant tumor and adenoma of lacrimal gland were retrospectively analyzed. Eight were benign and 12 were malignant. DCE-MRI was analyzed with the pharmacokinetic model proposed by Tofts and Kermode. There were three DCE quantitative parameters: Ktrans (volume transfer constant), Kep (rate constant) and Ve (extravascular extracellular space volume ratio). The dynamic curve was also analyzed. Z test was used to compare the different parameters between two groups.Chi-square test was used to analyze the difference of dynamic curves between groups. Receiver operating characteristic (ROC) curve was used to analyze the accuracy of parameters for differentiation of the two kinds of tumors.Results: Type of rapid washed in-platform was seen in 6 and 3 cases of pleomorphic adenoma and malignant tumor, respectively.Type of rapid washed inslowly washed out was seen in 2 and 9 cases of pleomorphic adenoma and malignant epithelial tumors. Value of Ktrans, Kep in malignant tumor were significantly higher than those of adenoma (Z=-2.533, -2.248, P<0.05). Ktrans is more sensitive than Kep to differentiate the pleomorphic adenoma and malignant epithelial tumors. When the cut off of Ktrans is 0.10, the sensitivity and specificity were 91.9% and 79.8%.Conclusions: Ktrans has a certain role in differential diagnosis for malignant epithelial tumor and pleomorphic adenoma of lacrimal gland.
[Keywords] Pleomorphic adenoma；Malignant epithelial tumor of lacrimal gland；DCE-MRI；Lacrimal gland

CHEN Yue-jie Imaging Center, Anshan Iron and Steel Group General Hospital, The 8th clinical hospital of China Medical University, Anshan 114002, China

XIA Shuang* Department of Radiology, First Central Hospital of Tianjin, Tianjin 300192, China

ZOU Yan-jun Imaging Center, Anshan Iron and Steel Group General Hospital, The 8th clinical hospital of China Medical University, Anshan 114002, China

ZHANG Ye Imaging Center, Anshan Iron and Steel Group General Hospital, The 8th clinical hospital of China Medical University, Anshan 114002, China

DING Ze Imaging Center, Anshan Iron and Steel Group General Hospital, The 8th clinical hospital of China Medical University, Anshan 114002, China

*Correspondence to: Xia S, E-mail: xiashuang77@163.com

Conflicts of interest   None.

Received  2014-11-11
Accepted  2015-01-15
DOI: 10.3969/j.issn.1674-8034.2015.02.007
DOI:10.3969/j.issn.1674-8034.2015.02.007.

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