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• Clinical Article •
Dynamic contrast-enhanced magnetic resonance imaging in differential diagnosis of solitary pulmonary nodules
MA Xiao-ling  ZHOU Shu-chang  XIA Li-ming 

DOI:10.3969/j.issn.1674-8034.2015.02.009.


[Abstract] Objective: This study is to assess the value of hemodynamic parameters of DCE-MR imaging in differentiating solitary pulmonary nodules(SPNs).Materials and Methods: A total of 62 patients (42 malignant nodules, 13 benign nodules and 7 active infections) with SPNs underwent DCE-MRI exams before bolus injection and after 15 phases since bolus injection of Gd-BOPTA , at the rate of 30 seconds. From the temporal-signal curves, the following analysis were taken: signal enhancement ratios at 1, 2, 4 minutes after bolus injection (SI1%、SI2%、SI4%) and the maximum enhancement ratio(MER ); time at the maximum enhancement ratio (Tmax); the steepest slope of time-signal curves (SS) and washout ratio.Results: It was found that SI1%、SI2%、SI4%、MER、SS for the malignant SPN group were significantly higher than those for the benign SPN group and significantly lower than those for the active infection group(P<0.05). With 2.23 and 0.63 as the threshold maximum enhancement ratio for distinguishing malignant nodules from benign nodules and active infection, the sensitivity, nagative predictive value, accuracy is 100%、100%、92%, respectively. Diagnostic accuracy is further improved combined with morphologic features of nodules.Conclusions: The hemodynamic parameters and morphologic characteristics of DCE-MRI may be a useful tool in differentiating malignant SPN from active infection SPN, as well as benign SPN.
[Keywords] Lung；Magnetic resonance imaging；Dynamic contrast enhancement

MA Xiao-ling Department of Radiology, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030, China

ZHOU Shu-chang Department of Radiology, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030, China

XIA Li-ming* Department of Radiology, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030, China

*Correspondence to: Xia LM, E-mail: cjr.xialiming@vip.163.com

Conflicts of interest   None.

Received  2014-12-01
Accepted  2014-12-29
DOI: 10.3969/j.issn.1674-8034.2015.02.009
DOI:10.3969/j.issn.1674-8034.2015.02.009.

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