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• Clinical Article •
Correlations between apparent diffusion coefficient values and histopathologic classification of breast invasive ductal carcinoma
ZHANG Wei  SU Dan-ke  LUO Ning-bin  JIN Guan-qiao  XIE Dong  WEI Wei  HUANG Xiang-yang  KANG Wei 

DOI:10.3969/j.issn.1674-8034.2015.02.010.


[Abstract] Objectives: The aim of this study was to evaluate the correlation between apparent diffusion coefficient (ADC) values and histopathologic classification of breast invasive ductal cancer.Materials and Methods: Sixty-six cases of breast cancer conformed by histopathology with histopathologic classification were involved in this retrospective study. The ADC values of lesions were measured and the mean (ADCmean) and minimum (ADCmin) of regions of interest (ROIs) were taken. The cases were divided into two groups, histopathologic classification and prognostic recurrence, according to the treatment and prognosis (histopathologic classification, lymph node status). The correlation was analyzed by using SPSS19.0 software (one-way ANOVA, LSD test and Spearman’ rank correlation coefficient method).Results: There were two groups, histopathologic classification group and prognostic recurrence group, which were divided three stages, respectively. ADCmean were 0.993×10-3 mm2/s、0.969×10-3 mm2/s、0.926×10-3 mm2/s, respectively, while ADCmin were 0.849×10-3 mm2/s、0.660×10-3 mm2/s、0.535×10-3 mm2/s in the former group, respectively, ADCmean were1.014×10-3 mm2/s、1.029×10-3 mm2/s、0.919×10-3 mm2/s, respectively, while ADCmin were 0.918×10-3 mm2/s、0.750×10-3 mm2/s、0.540×10-3 mm2/s in the latter group, respectively. ADCmean had no correlation with either histopathologic classification group or prognostic recurrence group. There was negative correlation between ADCmin and histopathologic classification group (r=-0.615, P=0.000) as well as prognostic recurrence group (r=-0.754, P=0.000).Conclusions: The ADCmin can be considered as an indicator of the development of medical plan before breast cancer surgery and the preliminary assessment of prognostic recurrence.
[Keywords] Breast cancer；Histopathologic classification；Apparent diffusion coefficient

ZHANG Wei Imaging center, The Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, China

SU Dan-ke Imaging center, The Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, China

LUO Ning-bin Imaging center, The Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, China

JIN Guan-qiao Imaging center, The Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, China

XIE Dong* Imaging center, The Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, China

WEI Wei Imaging center, The Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, China

HUANG Xiang-yang Imaging center, The Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, China

KANG Wei Imaging center, The Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, China

*Correspondence to: Xie D, E-mail: xiedong0310@163.com

Conflicts of interest   None.

Received  2014-09-26
Accepted  2014-12-26
DOI: 10.3969/j.issn.1674-8034.2015.02.010
DOI:10.3969/j.issn.1674-8034.2015.02.010.

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