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• Clinical Article •
Quantitative assessment of vascular kinetics using perfusion-weighted MRI for the differentiation of prostate cancer in the peripheral zone
FANG Jun-hua  MIN Xiang-de  FENG Zhao-yan  PENG Li  MA Yang-zhi  YE Zhang-qun  WANG Liang 

DOI:10.3969/j.issn.1674-8034.2015.02.011.


[Abstract] Objective: To assess vascular kinetics using perfusion-weighted MRI (PWI) in the differentiation of prostate cancer in the peripheral zone.Materials and Methods: Fifty-one patients with low T2 signal nodules in the prostate peripheral zone underwent PWI-MRI at 3 T were included in these study. Ktrans, Kep and Ve were compared between prostate cancer and benign nodules. Receiver operating characteristic(ROC) curve analyses were performed to determine the diagnostic accuracy of Ktrans, Kep and Ve.Results: The average values of Ktrans, Kep and Ve for prostate cancer and begin lesions were (0.150±0.046) vs (0.086±0.037), (0.518±0.181) vs (0.325±0.142) and (0.288±0.147) vs (0.306±0.141), respectively. There was statistically significant difference in Ktrans, Kep between prostate cancer and begin noduless (P<0.01). However, there was no statistically significant difference in Ve. The sensitivity, specificity for determining the prostate cancer of Ktrans, Kep were 86.11 %、80.6% and 79.32%、75.9%, respectively.Conclusions: Quantitative assessment of vascular kinetics using PWI is useful in the differentiation of prostate cancer in the peripheral zone.
[Keywords] Perfusion weighted MRI；Quantitative assessment；Prostate cancer；Differential diagnosis

FANG Jun-hua Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China; Department of Radiology, Zhijiang hospital of traditional Chinese medicine, Zhijiang 443200, China

MIN Xiang-de Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China

FENG Zhao-yan Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China

PENG Li Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China

MA Yang-zhi Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China

YE Zhang-qun Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China

WANG Liang* Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China

*Correspondence to: Wang L, E-mail: wang6@tjh.tjmu.edu.cn

Conflicts of interest   None.

Received  2014-10-27
Accepted  2014-12-26
DOI: 10.3969/j.issn.1674-8034.2015.02.011
DOI:10.3969/j.issn.1674-8034.2015.02.011.

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