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• Original Article •
Design and comparison of pulse sequence for detection of γ-aminobutyric acid using double quantum filter at 7 T MR spectroscopy
DONG Jing  QIU Qing-chun  SHEN Zhi-wei  ZHNAG Tao  NIE Ting-ting  JIA Yan-long  WU Ren-hua 

DOI:10.3969/j.issn.1674-8034.2015.02.012.


[Abstract] Objective: In this paper, the Double Quantum Filter (DQF) sequence and its functions and detection efficiency in measuring γ-aminobutyric acid (GABA) are studied, compared and developed in phantom experiments.The result can provide a basis for later human clinical.Materials and Methods: A point-resolved spectroscopy (PRESS)-localized double quantum filter (DQF) was applied to the detection of GABA at 7 T Magnetic resonance spectrum (MRS). At the same time, the detection efficiencies of different sequences were compared by changing the RF pulse waveform (Sinc and Gauss) of DQF in phantom experiments.Results: In phantom experiments, the optimal echo time, the editing efficiency and the degree of suppression of uncoupled resonances were examined after numerical analysis of the editing performance.Conclusions: Excellent GABA signal retention at 3.01 ppm and robust suppression of the signals of the overlapping metabolites was achieved due to Double Quantum Filter (DQF) sequence. The spectral editing efficiency was measured to be 30%-40%. The detection effect was different for using different RF pulse. It is noticed that the detection efficiency of Gauss RF pulse is reasonably high. The suppression effect of Cr was obvious. The Cho can be suppressed effectively, too. In our experiments, we found that different TR (Repetition time) or TE (Echo time) has different effects on the results of MRS detection efficiency in measuring γ-aminobutyric acid.
[Keywords] GABA；DQF；Pulse sequences；MRS；Spectral editing

DONG Jing Science College of Shantou University, Shantou 515063, guangdong, China; Department of Radiology, The Second Affiliated Hospital of Shantou University, Shantou 515041, Guangdong, China

QIU Qing-chun* Medical College Of Shantou University, Shantou 515041, Guangdong, China

SHEN Zhi-wei Science College of Shantou University, Shantou 515063, guangdong, China

ZHNAG Tao Department of Radiology, The Second Affiliated Hospital of Shantou University, Shantou 515041, Guangdong, China

NIE Ting-ting Department of Radiology, The Second Affiliated Hospital of Shantou University, Shantou 515041, Guangdong, China

JIA Yan-long Department of Radiology, The Second Affiliated Hospital of Shantou University, Shantou 515041, Guangdong, China

WU Ren-hua* Department of Radiology, The Second Affiliated Hospital of Shantou University, Shantou 515041, Guangdong, China

*Correspondence to: Qiu QC, E-mail: qcqiu@stu.edu.cn; Wu RH, E-mail: rhwu@stu.edu.cn

Conflicts of interest   None.

Received  2014-06-11
Accepted  2015-01-13
DOI: 10.3969/j.issn.1674-8034.2015.02.012
DOI:10.3969/j.issn.1674-8034.2015.02.012.

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