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• Clinical Article •
Spontaneous brain activity alterations in T2DM patients with mild cognitive impairment: a resting-state fMRI study
LIU Dai-hong  DUAN Shan-shan  ZHANG Jiu-quan  ZHANG Yan-wei  WEI Ping  WANG Jian 

DOI:10.3969/j.issn.1674-8034.2015.03.001.


[Abstract] Objective: To investigate the patterns of spontaneous brain activity alterations in type 2 diabetes mellitus (T2DM) with mild cognitive impairment (MCI) by analyzing the regional homogeneity (ReHo) and fractional amplitude of low-frequency fluctuations (fALFF).Materials and Methods: T2DM with MCI (D-MCI, n=21) and age-, sex-, and education-matched healthy control subjects (HC, n=25) were included in this study. T2WI, FLAIR, 3D-T1WI and resting-state fMRI data were collected by Siemens 3.0 T Trio MR scanner. ReHo and fALFF values were calculated respectively for intra-group and inter-group t-tests. Then correlation analysis were conducted between clinical data and ReHo/fALFF values extracted from significantly different brain regions.Results: Compared to healthy control subjects, D-MCI patients showed significantly increased ReHo values in most of the right superior frontal gyrus and partial left cerebelum areas, and decreased ReHo values in bilateral medial orbital part of superior frontal gyrus, right middle frontal gyrus, right inferior temporal gyrus, left middle occipital gyrus and right lingual gyrus. D-MCI patients also had increased fALFF values in left inferior temporal gyrus and bilateral anterior cingulate gyrus, and decreased fALFF values in right lingual gyrus. Moreover, inverse correlations were found between HbA1c and fALFF values of anterior cingulate gyrus (r=-0.482, P=0.027), MoCA scores and fALFF values of left inferior temporal gyrus (r=-0.547, P =0.010) in D-MCI group.Conclusions: D-MCI patients developed aberrant functional activities among brain regions associated with cognitive control network and visual processing. It may partially interpret the neural substrates in the progress of MCI for T2DM patients.
[Keywords] Type 2 diabetes mellitus；Mild cognitive impairment；Resting-state functional MRI；Regional homogeneity；Amplitude of low-frequency fluctuations

LIU Dai-hong Department of Radiology, the First Affiliated Hospital of Third Military Medical University, Chongqing 400038, China

DUAN Shan-shan Department of Endocrinology, the First Affiliated Hospital of Third Military Medical University, Chongqing 400038, China

ZHANG Jiu-quan Department of Radiology, the First Affiliated Hospital of Third Military Medical University, Chongqing 400038, China

ZHANG Yan-wei Department of Radiology, the First Affiliated Hospital of Third Military Medical University, Chongqing 400038, China

WEI Ping* Department of Endocrinology, the First Affiliated Hospital of Third Military Medical University, Chongqing 400038, China

WANG Jian* Department of Radiology, the First Affiliated Hospital of Third Military Medical University, Chongqing 400038, China

*Correspondence to: Wang J, E-mail: wangjian811@gmail.com. Wei P, E-mail: wp301 @sina.com

Conflicts of interest   None.

Received  2014-10-22
Accepted  2014-12-12
DOI: 10.3969/j.issn.1674-8034.2015.03.001
DOI:10.3969/j.issn.1674-8034.2015.03.001.

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