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• Clinical Article •
Evaluation of 1H-MRS in detecting active sacroiliitis in patients with axial spondyloarthritis
ZHUANG Ru-yao  GUO Shi-tao  HUANG Zhong-jie  HUANG Rui-bin  XIAO Zheng-yu  LIU Yuan 

DOI:10.3969/j.issn.1674-8034.2015.03.008.


[Abstract] Objective: To evaluate the value and characteristics of proton magnetic resonance spectroscopy (1H-MRS) in detecting active Sacroiliitis in patients with axial Spondyloarthritis (SpA).Materials and Methods: 1H-MRS and conventional MRI examinations were done oblique coronary on bilateral SIJs of 21 participants, involving 10 patients (the case group, including active a.nd inactive case groups) underwent clinical and conventional MRI evaluation for axial SpA active sacroiliitis and 11 healthy volunteers (the control group). The conventional MRI images were transmitted to two experienced radiologists respectively to read, evaluate at the workstation under the blind method. The spectrum image analysis was carried out with the LCModel software, and water to lipid ratio (WLR) was calculated for statistical analysis.Results: 1H-MRS spectra of the sacroiliac joints shows several metabolite peaks: the peak around 0.9 ppm is from the methyl protons, the 1.3 ppm, 1.6 ppm and 2.0 ppm are assigned to the methylene protons of the lipid chain, the 5.2 ppm is from the olefinic protons, and the water peak is at 4.7 ppm. The area under the water peak and the major lipid peak were used to calculate water to lipid ratio (WLR). The mean value of WLR were compared from all the three groups (active case group, 1.71±1.14, inactive case group, 0.43±0.08, and healthy control group, 0.42±0.23). The WLR of active case group were higher than both the inactive case group and the healthy control group, and the differences were statistically significant(Z=-4.46, -2.92, all P<0.05). However, the WLR between the inactive case group and the healthy control group was similar with no significant difference(Z=-0.87, P>0.05).Conclusions: 1H-MRS can quantify the bone marrow edema of sacroiliitis based on the conventional MRI, which maybe a new noninvasive method of assessing the activity of sacroiliitis.
[Keywords] Spinal diseases；Sacroiliitis；Magnetic resonance spectroscopy；Magnetic resonance imaging

ZHUANG Ru-yao Department of Radiology, the First Affiliated Hospital of Shantou University Medical College, Shantou 515041, China

GUO Shi-tao Department of Radiology, the First Affiliated Hospital of Shantou University Medical College, Shantou 515041, China

HUANG Zhong-jie Department of Radiology, the First Affiliated Hospital of Shantou University Medical College, Shantou 515041, China

HUANG Rui-bin Department of Radiology, the First Affiliated Hospital of Shantou University Medical College, Shantou 515041, China

XIAO Zheng-yu Department of Rheumatism, the First Affiliated Hospital of Shantou University Medical College, Shantou 515041, China

LIU Yuan* Department of Radiology, the First Affiliated Hospital of Shantou University Medical College, Shantou 515041, China

*Correspondence to: Liu Y, Email: liuy@stu.edu.cn

Conflicts of interest   None.

Received  2014-10-19
Accepted  2015-01-29
DOI: 10.3969/j.issn.1674-8034.2015.03.008
DOI:10.3969/j.issn.1674-8034.2015.03.008.

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