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• Clinical Article •
Comparative study of pancreatic fat content between newly-diagnosed patients with type 2 diabetes and healthy volunteers by chemical shift magnetic resonance imaging
CHAI Jun  LIU Peng  HONG Xu  YIN Jie  YU Heng-chi  SU Tian-hao  ZHANG Jie  SHI Kai-ning  JIN Er-hu 

DOI:10.3969/j.issn.1674-8034.2015.03.010.


[Abstract] Objective: To compare pancreatic fat content between newly-diagnosed patients with type 2 diabetes and healthy volunteers by chemical shift MRI, and explore their correlations with hepatic fat content.Materials and Methods: Seventy patients with newly-diagnosed type 2 diabetes and BMI、gender and age matched 31 healthy volunteers were recruited in this study. Fat content in the pancreas and liver was respectively measured, calculated, and compared with the sequence of double-echo chemical shift gradient-echo magnetic resonance imaging. The correlation between liver and pancreatic fat content was analyzed.Results: The average fat content of the liver and pancreas in patients with newly-diagnosed type 2 diabetes were higher than that in the healthy volunteers. Hepatic and pancreatic fat fraction were 9.87%±3.19% and 7.24%±2.38% (t=-4.56, P<0.05), as well as 5.15%±3.75% and 3.48%±1.97% (t=-3.01, P<0.05),respectively, in the two groups, and statistically significant differences among them were obvious. Correlation coefficients in the two samples of liver and pancreatic fat content were 0.053 (P>0.05) and 0.337 (P>0.05), both of them were not correlated each other.Conclusions: Hepatic and pancreatic fat content in newly-diagnosed patients with type 2 diabetes were higher than that of healthy volunteers, and the pancreatic and hepatic fat content were not correlated in the two groups.
[Keywords] Type 2 diabetes；Pancreatic fat content；Hepatic fat content；Magnetic resonance imaging

CHAI Jun Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China

LIU Peng Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China

HONG Xu* Department of Endocrinology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China

YIN Jie Department of Endocrinology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China

YU Heng-chi Department of Endocrinology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China

SU Tian-hao Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China

ZHANG Jie Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China

SHI Kai-ning GE Healthcare China, General Electric Company, No. 1 Yongchang North Road, Beijing 100176, China

JIN Er-hu* Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China

*Correspondence to: Jin EH, E-mail: erhujin@263.net. Hong X, E-mail: hxfriend@hotmail.com

Conflicts of interest   None.

Received  2014-11-25
Accepted  2015-01-19
DOI: 10.3969/j.issn.1674-8034.2015.03.010
DOI:10.3969/j.issn.1674-8034.2015.03.010.

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