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• Clinical Article •
Diffusion tensor imaging study of normal neonatal brain maturation
LIU Ling-ling  BO Ru-ting  YANG Wen-jun  LI Yan  TIAN Shu-ping  QIU Ying-ping  CHEN Zhi-qiang 

DOI:10.3969/j.issn.1674-8034.2015.04.003.


[Abstract] Objective: The purpose of this study was to investigate the developing status and characteristics of cerebral white matter during the neonatal period by using diffusion tensor imaging technique.Materials and Methods: In this study, 38 newborns were selected, including eighteen preterm infants (appropriate for gestational age) and twenty term infants (normal birth weight), they were divided into three groups according to their gestational age, fractional anisotropy obtained from each region of interest was analyzed.Results: The differences of FA values between left and right hemispheric white matter regions were no significant statistically. FA values for the peripheral white matter regions were lower than the values for deep white matter structures,in the deep white matter, the splenium of corpus callosum showed larger FA than genu, and the anterior limb of internal capsule showed smaller FA than posterior limb of internal capsule, the FA values for the splenium were higher than the values for the posterior limb of internal capsule. Among peripheral white matter, FA in central white matter (the level of central semiovale) were the highest, no significant differences were observed between anterior and posterior white matter (the level of central semiovale) (all P>0.05). FA values for all measured regions in group Ⅲ were more than that values in group Ⅰ, and the differences were significant statistically (all P<0.05), comparison between adjacent groups, there were significant statistically only in part of regions of interest.Conclusion: Diffusion tensor imaging technique is very usefull in the study of neonatal white matter maturation, FA value can assess myelin development quantitatively.
[Keywords] Neonate；Brain；Myelin sheath；Diffusion magnetic resonance imaging

LIU Ling-ling Ningxia Medical University, Yinchuan 750004, China

BO Ru-ting Ningxia Medical University, Yinchuan 750004, China

YANG Wen-jun Key Laboratory of Fertility Maintenance, Ministry of Education, Ningxia Medical University, Yinchuan 750004, China

LI Yan Department of Radioloy, General hospital of Ningxia Medical University, Yinchuan 750004, China

TIAN Shu-ping Department of Neonatology, General hospital of Ningxia Medical University, Yinchuan 750004, China

QIU Ying-ping Department of Neonatology, General hospital of Ningxia Medical University, Yinchuan 750004, China

CHEN Zhi-qiang* Department of Radioloy, General hospital of Ningxia Medical University, Yinchuan 750004, China

*Correspondence to: Chen ZQ, E-mail: czq642000@163.com

Conflicts of interest   None.

Received  2015-02-01
Accepted  2015-03-02
DOI: 10.3969/j.issn.1674-8034.2015.04.003
DOI:10.3969/j.issn.1674-8034.2015.04.003.

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