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• Clinical Article •
The diagnostic value of triple-negative breast cancer using 3.0 T MRI
WANG Qi  CHANG Xiao-dan 

DOI:10.3969/j.issn.1674-8034.2015.04.008.


[Abstract] Objective: To invstigate the specific findings of triple-negative breast cancer (TNBC) with dynamic contrast-enhanced MRI and DWI, and to provide the reference for presurgical evaluation.Materials and Methods: Two hundred and fifty-one patients with breast cancer who underwent operation from Augest, 2012 to June, 2014 were included. Seventy patients were TNBC, while 181 patients were ER(+)/PR(+)/HER-2(-) cancer. Comparing the dynamic contrast-enhanced breast MRI and DWI imaging findings of these two subtypes and making the appropriate statistical analysis.Results: Compared to ER(+)/PR(+)/HER-2(-) tumors, TNBC cancers were presented with single (P=0.018), larger tumor size (P=0.002), higher histologic grade (P<0.001). MRI features associated with TNBC tumors included mass enhancement (P=0.026), lobulated (P<0.001), smooth margins (P=0.005), ring-enhancement (P<0.001) and areas of intratumoral high T2 signal intensity (P <0.001). Moreover, the TNBC appeared higher ADC value (P=0.031).Conclusions: Preoperative MRI is helpful in differentiating TNBC and contrast enhanced ER (+) /PR (+) /HER-2(-) cancer. It would be one of the most important noninvasive examination methods to preoperatively evaluate the breast cancer, and provide imaging basis for clinical treatment.
[Keywords] Triple-negative breast cancer；Magnetic resonance imaging；Diffusion weighted imaging

WANG Qi Department of Radiology, Zhongshan Hospital Affiliated to Dalian University, Dalian 116001, China

CHANG Xiao-dan* Department of Radiology, Zhongshan Hospital Affiliated to Dalian University, Dalian 116001, China

*Correspondence to: Chang XD, E-mail: 13384111832@163.com

Conflicts of interest   None.

Received  2014-11-11
Accepted  2014-12-31
DOI: 10.3969/j.issn.1674-8034.2015.04.008
DOI:10.3969/j.issn.1674-8034.2015.04.008.

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