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• Clinical Article •
The correlation between DCE-MRI parameters and pathological characteristics in rectal cancer
XIE Zong-yuan  XU Xiang-jiu  HUANG Gang  ZHOU Xing  MA Xiao-mei  WANG Zhi-min  TIE Ping  ZHANG Qing 

DOI:10.3969/j.issn.1674-8034.2015.04.009.


[Abstract] Objective: To evaluate the relationship between the the characteristics of dynamic contrast-enhanced MRI (DCE-MRI) parameters and the degree of pathologic differentiation as well as Dukes staging in rectal cancer.Materials and Methods: A retrospective investigation of DCE-MRI image of fifty six patients with rectal cancer confirmed by surgical pathology was made, the time intensity curve (TIC) was rendered, the Ktrans, Ve, Kep parameters graphs were constructed, the characteristics of the TIC, Ktrans, Ve, Kep values as well as the correlation between the degree of tumor differentiation and Dukes stage were analyzed.Results: The TIC of rectal cancer and normal rectal wall around the tumor were divided into three types, in which 8 cases belonged to the type two, 48 cases belonged to the type three. The normal rectal wall around the tumor 41 cases belonged to the type one, 15 cases belonged to the type two. The Ktrans value increase with the worsening of the degree of differentiation and the increase of Dukes staging (P<0.01).There was no statistically significant difference of Ve and Kep values.Conclusions: DCE-MRI can reflect the haemodynamics of internal tumors, TIC and Ktrans value have certain correlation with the degree of pathologic differentiation and Dukes staging. TIC and Ktrans may be used to evaluate the malignancy degree of rectal cancer.
[Keywords] Rectal cancer；Magnetic resonance imaging；Dynamic contrast-enhanced；Time-intensity curve；Volume transfer constant

XIE Zong-yuan Ningxia Medical University, Yinchuan 750000, China

XU Xiang-jiu* Department of Radioligy, Gansu Province Hospital, Lanzhou 730000, China

HUANG Gang Department of Radioligy, Gansu Province Hospital, Lanzhou 730000, China

ZHOU Xing Department of Radioligy, Gansu Province Hospital, Lanzhou 730000, China

MA Xiao-mei Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China

WANG Zhi-min Department of Radioligy, Gansu Province Hospital, Lanzhou 730000, China

TIE Ping Department of Radioligy, Gansu Province Hospital, Lanzhou 730000, China

ZHANG Qing Ningxia Medical University, Yinchuan 750000, China

*Correspondence to: Xu XJ, E-mail: xvxiangjiu@sina.com

Conflicts of interest   None.

Received  2015-01-05
Accepted  2015-02-12
DOI: 10.3969/j.issn.1674-8034.2015.04.009
DOI:10.3969/j.issn.1674-8034.2015.04.009.

[1]
赵金丽，管海涛，李敏达，等. MR动态增强扫描结合T2*WI首过灌注成像诊断乳腺肿瘤的价值．磁共振成像, 2014, 5(1): 5(1):54-59.
[2]
李敏，金真，李功杰，等．乳腺动态增强MRI参数与肿瘤血管的相关性及其鉴别诊断价值．磁共振成像, 2010, 1(1): 36-42.
[3]
Kim H, Folks KD, Guo L, et al. DCE-MRI detects early vascular response in breast tumor xenografts following anti-DR5 therapy. Mol Imaging Biol, 2011, 13(1): 94-103.
[4]
刘莉，吴宁，欧阳汉，等．前列腺癌动态增强MRI的多样性表现及特点.中国医学影像技术, 2011, 27(12): 2506-2509.
[5]
Franiel T, Hamm B, Hricak H. Dynamic contrast-enhanced magnetic resonance imaging and pharmacokinetic models in prostate cancer. Eur Radiol, 2011, 21(3): 616-626.
[6]
Tofts PS, Brix G, Buckley DL, et al. Estimating kinetic parameters from dynamic contrast-enhanced T(1)-weighted MRI of a diffusable tracer:Standardized quantities and symbols. J Magn Reson Imaging, 1999,10(3): 223-232.
[7]
张盛箭，彭卫军，周良平．动态增强MRI基本原理及其在前列腺癌中的应用．中国医学影像技术, 2010, 26(2): 378-380．
[8]
Wang H, Li J, Chen F, et al. Morphological,functional and metabolic imaging biomarkers:assessment of vascular-disrupting effect on rodent liver tumors. Eur Radiol, 2010, 20(8): 2013-2026.
[9]
Yao WW, Zhang H, Ding B, et al. Rectal cancer: 3D dynamic contrast-enhanced MRI；correlation with microvascular density and clinicopathological features. Radiol Med, 2011, 116(3): 366-374.
[10]
周妮娜，陈敏，王文超，等．动态增强磁共振成像对直肠癌术前新辅助治疗疗效的评价．磁共振成像, 2010, 1(2): 103-109.
[11]
Yankeelov TE, Gore JC. Dynamic contrast enhanced magnetic resonance imaging in oncology:theory,data acquisition,analysis,and examples. Curr Med Iamging Rev, 2009, 3(2): 91-107.
[12]
Kim DJ, Kim JH, Lim JS, et al. Restaging of rectal cancer with MR imaging after concurrent chemotherapy and radiation therapy. Radiographics, 2010, 30(2): 503-516.

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