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• Clinical Article •
The correlation between DCE-MRI parameters and pathological characteristics in rectal cancer
XIE Zong-yuan  XU Xiang-jiu  HUANG Gang  ZHOU Xing  MA Xiao-mei  WANG Zhi-min  TIE Ping  ZHANG Qing 

DOI:10.3969/j.issn.1674-8034.2015.04.009.


[Abstract] Objective: To evaluate the relationship between the the characteristics of dynamic contrast-enhanced MRI (DCE-MRI) parameters and the degree of pathologic differentiation as well as Dukes staging in rectal cancer.Materials and Methods: A retrospective investigation of DCE-MRI image of fifty six patients with rectal cancer confirmed by surgical pathology was made, the time intensity curve (TIC) was rendered, the Ktrans, Ve, Kep parameters graphs were constructed, the characteristics of the TIC, Ktrans, Ve, Kep values as well as the correlation between the degree of tumor differentiation and Dukes stage were analyzed.Results: The TIC of rectal cancer and normal rectal wall around the tumor were divided into three types, in which 8 cases belonged to the type two, 48 cases belonged to the type three. The normal rectal wall around the tumor 41 cases belonged to the type one, 15 cases belonged to the type two. The Ktrans value increase with the worsening of the degree of differentiation and the increase of Dukes staging (P<0.01).There was no statistically significant difference of Ve and Kep values.Conclusions: DCE-MRI can reflect the haemodynamics of internal tumors, TIC and Ktrans value have certain correlation with the degree of pathologic differentiation and Dukes staging. TIC and Ktrans may be used to evaluate the malignancy degree of rectal cancer.
[Keywords] Rectal cancer；Magnetic resonance imaging；Dynamic contrast-enhanced；Time-intensity curve；Volume transfer constant

XIE Zong-yuan Ningxia Medical University, Yinchuan 750000, China

XU Xiang-jiu* Department of Radioligy, Gansu Province Hospital, Lanzhou 730000, China

HUANG Gang Department of Radioligy, Gansu Province Hospital, Lanzhou 730000, China

ZHOU Xing Department of Radioligy, Gansu Province Hospital, Lanzhou 730000, China

MA Xiao-mei Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China

WANG Zhi-min Department of Radioligy, Gansu Province Hospital, Lanzhou 730000, China

TIE Ping Department of Radioligy, Gansu Province Hospital, Lanzhou 730000, China

ZHANG Qing Ningxia Medical University, Yinchuan 750000, China

*Correspondence to: Xu XJ, E-mail: xvxiangjiu@sina.com

Conflicts of interest   None.

Received  2015-01-05
Accepted  2015-02-12
DOI: 10.3969/j.issn.1674-8034.2015.04.009
DOI:10.3969/j.issn.1674-8034.2015.04.009.

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