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• Clinical Article •
Metabolic concentrations alternations of bilateral prefrontal lobes and hippocampus after taking codeine phosphate: quantified by 1H-MRS and LCModel
LAN Hai-long  WU Mei-lian  CAO Zhen  XIAO Ye-yu  WU Ren-hua 

DOI:10.3969/j.issn.1674-8034.2015.05.001.


[Abstract] Objective: Absolute quantitative analysis of healthy youth in the bilateral prefrontal lobes and hippocampus were performed and offered preliminary stage experimental data, in order to supply a reference for the further study of codeine habituation.Materials and Methods: Twenty right-handed healthy youth were included [10 males, 10 females, mean age (24.9±1.9) years]. MRS data were collected by GE 1.5 T MR scanner, using point resolved selective spectroscopy (PRESS) sequence (TE/TR 30 ms/3000 ms). The regions of interest (ROI) were located over the bilateral prefrontal lobes and hippocampus, size of ROI was 2 cm × 2 cm × 2 cm. The data of spectra were post-processed by LCModel software and the concentrations of metabolites were ultimately measured. The metabolite concentration of each people was analyzed by paired-samples t test of SPSS19.0.Results: After taking codeine phosphate, the concentration of GPC increased 0.254 mmol/L in the left prefrontal lobe while Ins declined 0.988 mmol/L, which reached statistical significance (n=13, P<0.05. n=12, P<0.05). The alterations of metabolites in right prefrontal lobe and bilateral hippocampus did not reach statistical significance.Conclusions: The metabolites' concentrations of the left prefrontal lobes would change with oral codeine phosphate. GPC increased in the left prefrontal lobe while Ins declined, which was considered related with the abatement of neurotransmitter.
[Keywords] Codeine；Brain diseases；Magnetic resonance spectroscopy；Cerebral metabolite；Quantitation

LAN Hai-long Medical Imaging Center, Xiaolan Affiliated Hospital, Southern Medical University, Zhongshan 528415, China; Medical Imaging Center, the 2nd Affiliated Hospital, Medical College of Shantou University, Shantou 515041, China

WU Mei-lian Medical Imaging Center, the 2nd Affiliated Hospital, Medical College of Shantou University, Shantou 515041, China

CAO Zhen Medical Imaging Center, the 2nd Affiliated Hospital, Medical College of Shantou University, Shantou 515041, China

XIAO Ye-yu* Medical Imaging Center, the 2nd Affiliated Hospital, Medical College of Shantou University, Shantou 515041, China

WU Ren-hua Medical Imaging Center, the 2nd Affiliated Hospital, Medical College of Shantou University, Shantou 515041, China

*Correspondence to: Xiao YY, E-mail: xyyu73@163.com

Conflicts of interest   None.

Received  2014-05-10
Accepted  2014-08-20
DOI: 10.3969/j.issn.1674-8034.2015.05.001
DOI:10.3969/j.issn.1674-8034.2015.05.001.

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