Share：
Share this content in WeChat
X
[Chinese][PDF]92980
• Clinical Article •
Quantitative research of diffusion tensor imaging in cognitive impairment of Parkinson's disease
SHI Feng  GAO Yang  QIAO Peng-fei  LI Shu-ling  NIU Guang-ming 

DOI:10.3969/j.issn.1674-8034.2015.05.002.


[Abstract] Objectives: To analyze the microstructural white matter changes of Parkinson's disease (PD) patients, study the value of diffusion tensor imaging (DTI) in the diagnosis of PD with cognitive impairment.Materials and Methods: Thirty PD patients were brought into research, including 18 patients with cognitive impairment (PD-CI) and 12 patients with cognitive normal (PD-CN), at the same time, 30 healthy volunteers were selected as the control group with gender, age, education matched. Conventional MRI and DTI examination were performed between two groups, Hoehn-Yahr (H-Y) and montreal cognitive assessment (MoCA) were evaluated before the MRI exam. On T2WI (b=0) image combined with DTI color coding graph, manually drawing the round region of interest to respectively measure the value of FA and ADC on substantia nigra, red nucleus, globus pallidus, putamen nucleus, the head of caudate nucleus, thalamus, frontal white matter, temporal white matter, parietal white matter, occipital white matter, and statistical analysis were conducted.Results: Compared with the healthy control group, the FA value of substantia nigra, putamen nucleus, the head of caudate nucleus, frontal white matter in PD patients obviously decrease (P<0.05), the ADC value of frontal and temporal white matter is obviously increase (P<0.05). There is statistical difference about the ADC value of frontal white matter between groups PD-CI and PD-CN (P<0.05). The FA and ADC value on each part of patients group have no obvious correlation with H-Y and MoCA scores (P>0.05).Conclusions: The substantia nigrastriatum loop neurons of PD patients have widespread damage, the injury of frontal white matter is probably key factor of combined cognitive impairment of PD. The appraisal of the microstructural white matter changes by using DTI may be one of the important clues to early diagnosis and illness monitoring about Parkinson's disease.
[Keywords] Parkinson disease；Cognition disorders；Diffusion magnetic resonance imaging

SHI Feng Department of MRI, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China; Department of Radiology, the Inner Mongolia Autonomous Region Hospital of traditional Chinese Medicine, Hohhot 010020, China

GAO Yang Department of MRI, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China

QIAO Peng-fei Department of MRI, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China

LI Shu-ling Department of MRI, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China

NIU Guang-ming* Department of MRI, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China

*Correspondence to: Niu GM, E-mail: cjr.niuguangming@vip.163.com

Conflicts of interest   None.

Received  2015-02-11
Accepted  2015-04-05
DOI: 10.3969/j.issn.1674-8034.2015.05.002
DOI:10.3969/j.issn.1674-8034.2015.05.002.

[1]
Zhang ZX, Roman GC, Hong Z, et al. Parkinson’s disease in China:prev-alence in Beijing, Xian, and Shanghai. Lancet, 2005, 365(9459): 595-597.
[2]
Caslake R, Moore JN, Gordon JC, et al. Changes in diagnosis with follow-up in an incident cohort of patients with parkinsonism. J Neurol Neurosurg Psychiatry, 2008, 79(11): 1202-1207.
[3]
Hodaie M, Neimat JS, Lozano AM. The dopaminergic nigrostriatal system and Parkinson’s disease:molecular events in development, disease, and cell death,and new therapeutic strategies. Neurosurgery, 2007, 60(1): 17-30.
[4]
Lang AE, Lozano AM. Parkinson’s disease. First of two parts. N Engl J Med, 1998, 339(15): 1044-1053.
[5]
Lang AE, Lozano AM. Parkinson’s disease. Second of two parts. N Engl J Med, 1998, 339(16): 1130-1143.
[6]
Ekman U, Eriksson J, Forsgren L, et al. Functional brain activity and presynaptic dopamine uptake in patients with Parkinson’s disease and mild cognitive impairment: a cross-sectional study. Lancet Neurol, 2012, 11(8): 679-687.
[7]
Du G, Lewis MM, Styner M, et al. Combined R2* and diffusion tensor imaging changes in the substantia nigra in Parkinson’s Disease. Mov Disord, 2011, 26(9): 1627-1632.
[8]
陈燕生，方元，史文宗，等．早期帕金森病黑质致密部FA值量化研究．放射学实践, 2014, 29(4): 387-389.
[9]
Youn J, Lee JM, Kwon H, et al. Alterations of mean diffusivity of pedu-nculopontine nucleus pathway in Parkinson's disease patients with freezing of gait. Parkinsonism Relat Disord, 2015, 21(1): 12-17.
[10]
Pereira JB, Svenningsson P, Weintraub D, et al. Initial cognitive decline is associated with cortical thinning in early Parkinson disease. Neurology, 2014, 82(22): 2017-2025.
[11]
彭帅，陈敏，李春媚，等．帕金森病静息态脑功能MRI研究．磁共振成像, 2014, 5(5): 321-327.
[12]
Nicoletti G, Tonon C, Lodi R, et al. Apparent diffusion coefficient of the superior cerebellar peduncle differentiates progressive supranuclear palsy from Parkinson's disease. Mov Disord, 2008, 23(16): 2370-2376.
[13]
Emre M. Dementia associated with Parkinson's disease. Lancet Neurol, 2003, 2(4): 229-237.
[14]
邓兵梅，刘雁，杨红军，等．非痴呆早期帕金森病患者脑白质微结构的改．中风与神经疾病杂志, 2014, 31(1): 57-60.
[15]
成义仁，刘琨，李玉梅，等．帕金森病患者认知功能与脑电活动及脑影像学改变的相关性研究．神经疾病与精神卫生, 2007, 7(1): 7-10.
[16]
Hely MA, Morris JG, Reid WG, et al. Sydney Multicenter Study of Parkinson’s disease: non-L-dopa-responsive problems dominate at 15 years. Mov Disord, 2005, 20(2): 190-199.
[17]
Janvin CC, Larsen JP, Aarsland D, et al. Subtypes of mild cognitive impairment in Parkinson’s disease: progression to dementia. Mov Disord, 2006, 21(9): 1343-1349.
[18]
Stocchi F, Brusa L. Cognition and emotion in different stages and subtypes of Parkinson’s disease. J Neurology, 2000, 247(Suppl 2): 114-121.
[19]
Pagonabarraga J, KuIisevsky J. Cognitive impairment and dementia in Parkinson’s disease. NeurobioI Dis, 2012, 46(3): 590-596.
[20]
Matsui H, Nishinaka K, Oda M, et al. Depression in Parkinson’s disease: diffusion tensor imaging study. J Neurol, 2007, 254(9): 1170-1173.
[21]
Deng B, Zhang Y, Wang L, et al. Diffusion tensor imaging reveals white matter changes associated with cognitive status in patients with Parkinson’s disease. Am J Alzheimers Dis Other Demen, 2013, 28(2): 154-164.
[22]
邓远飞，罗筱，曾文双，等．帕金森病认知障碍弥散张量成像初步研究．中国神经精神疾病杂志, 2014, 40(8): 489-493.
[23]
Chan LL, Rumpel H, Yap K, et al. Case control study of diffusion tensor imaging in Parkinson's disease. J Neurol Neurosurg Psychiatry, 2007, 78(12): 1383-1386.
[24]
舒红格，漆剑频，朱文珍，等．帕金森病的扩散张量成像研究．中国医学影像技术, 2010, 26(4): 643-646.

PREV Metabolic concentrations alternations of bilateral prefrontal lobes and hippocampus after taking codeine phosphate: quantified by 1H-MRS and LCModel
NEXT The study of DTI in bilateral optic radiation in relapsing-remitting multiple sclerosis and relapsing neuromyelitis optica
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn