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• Clinical Article •
The study of DTI in bilateral optic radiation in relapsing-remitting multiple sclerosis and relapsing neuromyelitis optica
ZHANG Xiao-hui  LI Yong-mei  ZENG Chun  WANG Jing-jie  LI Ying  LIU Yi  ZHANG Xiao-ling  LUO Ya-xi 

DOI:10.3969/j.issn.1674-8034.2015.05.003.


[Abstract] Objective: To investigate whether there are differences in diffusion tensor imaging (DTI) indexes between relapsing-remitting multiple sclerosis (RRMS) and relapsing neuromyelitis optica (RNMO) in the apparent normal optic radiation by DTI.Materials and Methods: Twenty cases RRMS and RNMO patients and 20 cases age-and sex-matched healthy volunteers received DTI. Fractional anisotropy (FA) value and mean diffusivity (MD) value were acquired on bilateral optic radiation individually, and all RRMS and RNMO patients were evaluated by the expanded disability status scale (EDSS). We compared FA and MD value of bilateral optic radiation in each group using t test. We compared FA and MD value of bilateral optic radiation between each patient group and normal control group using one-way analysis of variance (one-way ANOVA) and Dunnett-t test. To evaluate the association between DTI value and EDSS score we used Spearman. All statistical analyses were conducted using SPSS 17.0.Results: (1) In each group, The bilateral optic radiation FA value (t=0.41, P=0.68. t=0.10, P=0.92. t=0.63, P=0.54) and MD value (t=0.72, P=0.48. t=0.20, P=0.84. t=0.20, P=0.84) were not significantly different (P>0.05), respectively. FA value (P=0.00.P=0.00) of bilateral optic radiation in patient group was significantly lower than normal control group, while MD value (P=0.00, P=0.00) was significantly higher than normal control group (P<0.05). FA value (P=0.02) in RNMO patients was decreased than that of the RRMS patients, but the MD value (P=0.50) was not significantly different. (2) There were not correlations between both FA (r=-0.19, P=0.42. r=0.20, P=0.41) and MD (r=0.11, P=0.64. r=-0.33, P=0.15) values of bilateral optic radiation and EDSS scores (P>0.05) in RRMS and RNMO.Conclusions: The appearing-normal optic radiation of both RRMS and RNMO patients was involved, but the involvement degree was not consistent in the two groups. FA value has potential applications to identify MS and NMO, as an important biological indicator for monitoring clinical course progress.
[Keywords] Magnetic resonance imaging；Multiple sclerosis；Neuromyelitis optica

ZHANG Xiao-hui Department of Radiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

LI Yong-mei* Department of Radiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

ZENG Chun Department of Radiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

WANG Jing-jie Department of Radiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

LI Ying Department of Radiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

LIU Yi Department of Radiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

ZHANG Xiao-ling Department of Radiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

LUO Ya-xi Department of Radiology, the 5th People's Hospital of Chongqing, Chongqing 400062, China

*Correspondence to: Li YM, E-mail: lymzhang70@aliyun.com

Conflicts of interest   None.

Received  2015-02-12
Accepted  2015-04-06
DOI: 10.3969/j.issn.1674-8034.2015.05.003
DOI:10.3969/j.issn.1674-8034.2015.05.003.

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