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• Clinical Article •
1H MRS quantification of ectopic fat accumulation in pancreas and its relationship with islet beta-cell function in patients with newly diagnosed type 2 diabetes mellitus
LIU Peng  CHAI Jun  HONG Xu  YIN Jie  YU Heng-chi  SU Tian-hao  ZHANG Jie  SHI Kai-ning  JIN Er-hu 

Both Jin EH and Hong X are corresponding author DOI:10.3969/j.issn.1674-8034.2015.05.009.


[Abstract] Objective: To in vivo quantify the pancreatic fat content in newly diagnosed type 2 diabetes mellitus (T2DM) by applying 1H MRS, and investigate its relationships with liver fat content, serum triglyceride (TG) and islet beta-cell function.Materials and Methods: Fifty-eight T2DM subjects and thirty-two volunteers without T2DM were included in this study. All T2DM subjects were newly diagnosed according to the clinical criteria without any therapy. The pancreatic spectroscopy of at least one location (head, body, and tail) and liver spectroscopy at right lobe were acquired by single-voxel PRESS sequence on 3.0 T MR scanner. The pancreas fat content (PFC) and liver fat content (LFC) were calculated in each case. Spearman correlations between PFC and LFC, TG, the body mass index (BMI), the fasting blood-glucose (FBG), the fasting serum insulin (FINS), the homeostasis model assessment of insulin resistance (HOMA-IR), the homeostasis model assessment-β (HOMA-β) and the Lee-Bennett islet beta cell function index (MBCI) were performed in order to visualize their relationships.Results: The mean values of PFC in 58 T2DM subjects and 32 volunteers without T2DM were (16.09±6.27)% and (14.56±7.97)%, respectively, there is no statistically difference (P>0.05). The LFC in 32 T2DM subjects and all volunteers without T2DM was successfully measured, the mean values were (21.13±14.44)% and (12.43±12.19)%, respectively, there was statistically significant differences (P=0.006). Moderate to low correlations were found between PFC and LFC (r=0.502, P=0.003), TG (r=0.467, P=0.007), and BMI (r=0.362, P=0.042) in volunteers without T2DM, but no statistical correlation was found between PFC and LFC, TG, BMI, FBG, FINS, HOMA-IR, HOMA-β, and MBCI (r<0.15, P>0.05) in T2DM subjects.Conclusions: No correlation was found between PFC and LPF, TG, and islet beta-cell function in patients with newly diagnosed T2DM.
[Keywords] Adiposity；Diabetes mellitus, Type 2；Magnetic resonance spectroscopy；Pancreatic diseases；Fatty liver

LIU Peng Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China

CHAI Jun Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China

HONG Xu* Department of Endocrinology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China

YIN Jie Department of Endocrinology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China

YU Heng-chi Department of Endocrinology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China

SU Tian-hao Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China

ZHANG Jie Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China

SHI Kai-ning GE Healthcare China, General Electric Company, No. 1 Yongchang North Road, Beijing 100176, China

JIN Er-hu* Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China

*Correspondence to: Jin EH, E-mail: erhujin@263.net Hong X, E-mail: hxfriend@ hotmail.com

Conflicts of interest   None.

Received  2014-12-23
Accepted  2015-03-02
DOI: 10.3969/j.issn.1674-8034.2015.05.009
Both Jin EH and Hong X are corresponding author DOI:10.3969/j.issn.1674-8034.2015.05.009.

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