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• Clinical Article •
The preliminary study of resting-state functional magnetic resonance in patients with leukoaraiosis
ZHONG Yi-xin  ZHAO Jian-nong  ZHOU Zhi-ming  SHI Jiang-yong  ZHONG Wei-jia 

DOI:10.3969/j.issn.1674-8034.2015.06.003.


[Abstract] Objective: To investigate the abnomality of spontaneous neural activity in patients with leukoaraiosis using blood oxygenation level dependent-functional magnetic resonance imaging (BOLD-fMRI).Materials and Methods: Nineteen patients with mild LA(The mild LA group), twenty-one patients with severe LA (The severe LA group) and nineteen age-matched healthy controls(The HC group) underwent the rs-fMRI scans, and the ALFF maps were computed and analysed.Results: Compared with the mild LA group, the severe LA group demonstrated decreased ALFF in the left precuneus and right angular gyrus(P<0.05, corrected). Moreover, compared with healthy controls, the severe LA group showed significantly decreased ALFF in the left precuneus, right angular gyrus and right middle frontal gyrus (P<0.05, corrected).Conclusion: Patients with LA show abnormality of spontaneous neural activity.
[Keywords] Leukoencephalopathies；Magnetic resonance imaging；Amplitude of low-frequency fluctuation；Neurons

ZHONG Yi-xin Department of radiology, the Second Affiliated Hospital of Chongqing medical University, Chongqing 400010, China

ZHAO Jian-nong* Department of radiology, the Second Affiliated Hospital of Chongqing medical University, Chongqing 400010, China

ZHOU Zhi-ming Department of radiology, the Second Affiliated Hospital of Chongqing medical University, Chongqing 400010, China

SHI Jiang-yong Department of radiology, the Second Affiliated Hospital of Chongqing medical University, Chongqing 400010, China

ZHONG Wei-jia Department of radiology, the Second Affiliated Hospital of Chongqing medical University, Chongqing 400010, China

*Correspondence to: Zhao JN, E-mail: zhaojiannong@tom.com

Conflicts of interest   None.

Received  2015-04-08
Accepted  2015-05-14
DOI: 10.3969/j.issn.1674-8034.2015.06.003
DOI:10.3969/j.issn.1674-8034.2015.06.003.

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