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• Clinical Article •
The study of resting state functional magnetic resonance and fiber tracking in multiple sclerosis patients with simple spinal cord involvement
LIU Yi  LI Yong-mei  ZENG Chun  WANG Jing-jie  ZHANG Xiao-hui  ZHANG Xiao-ling  LI Ying 

DOI:10.3969/j.issn.1674-8034.2015.06.004.


[Abstract] Objective: To explore the changes of the brain functional activity and the integrity of brain white matter in multiple sclerosis patients with simple spinal cord involvement (MS-SSCI) by using resting-state functional magnetic resonance imaging (RS-fMRI) and fiber tracking.Materials and Methods: Amplitude of low-frequency fluctuation (ALFF) was compared between 20 MS-SSCI and 20 age-and gender-matched normal controls by using RS-fMRI and the brain regions showing significant difference between groups were defined as the regions of interest (ROI). Fiber tracking was then used to reconstruct the white matter fiber within ROI and then the fractional anisotropy (FA) and the apparent diffusion coefficient (ADC) were compared between the two groups. The relationships between ALFF, FA, ADC of ROI and the expanded disability states scale (EDSS) scores were further explored.Results: Compared with the controls, ALFF decreased in the right hippocampus, but increased in the left middle frontal lobe, left posterior cingulate gyrus and right middle occipital lobe (two-sample t test, after AlphaSim correction, P<0.01, voxel size> 40), MS-SSCI showed significant difference of FA (tright hippocampus=2.099, Pright hippocampus=0.042) and ADC (tright hippocampus=-2.053, Pright hippocampus=0.047)in the right hippocampus; A significant correlation between EDSS scores and ALFF was noted only in the left posterior cingulate gyrus, while no significant correlation between structural parameters and EDSS scores.Conclusion: Our results detected functional and structural abnormalities in MS-SSCI. Moreover, fluctuational abnormalities was closely related to cognitive impairment.
[Keywords] Multiple sclerosis；Spinal cord diseases；Magnetic resonance imaging；Fiber tracking

LIU Yi Department of Radiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

LI Yong-mei* Department of Radiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

ZENG Chun Department of Radiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

WANG Jing-jie Department of Radiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

ZHANG Xiao-hui Department of Radiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

ZHANG Xiao-ling Department of Radiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

LI Ying Department of Radiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

*Correspondence to: Li YM, E-mail: lymzhang70@aliyun.com

Conflicts of interest   None.

Received  2015-03-18
Accepted  2015-04-23
DOI: 10.3969/j.issn.1674-8034.2015.06.004
DOI:10.3969/j.issn.1674-8034.2015.06.004.

[1]
Raz E, Bester M, Sigmund EE, et al. A Better Characterization of Spinal Cord Damage in Multiple Sclerosis: A Diffusional Kurtosis Imaging Study. AJNR Am J Neuroradiol, 2013, 34(9): 1846-1852.
[2]
彭帅，陈敏，李春媚，等．帕金森病静息态脑功能MRI研究．磁共振成像, 2014，5(5): 321-327.
[3]
Liu Y, Liang P, Duan Y, et al. Brain plasticity in relapsing-remitting multiple sclerosis: evidence from resting-state fMRI. J Neurol Sci, 2011, 304(1-2): 127-131.
[4]
姚青，陈德基，刘克，等．颅脑磁共振弥散张量成像在多发性硬化患者的初步研究．广州医学院学报, 2011, 39(1): 19-23.
[5]
Selchen D, Bhan V, Blevins G, et al. MS, MRI, and the 2010 McDonald criteria: a Canadian expert commentary. Neurology, 2012, 79(23): 1-15.
[6]
Wingerchuk DM, Lennon VA, Pittock SJ, et al. Revised diagnostic criteria for neuromyelitis optica. Neurology, 2006, 66(10): 1485-1489.
[7]
Polman CH, Reingold SC, Banwell B, et al. Diagnosis criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol, 2011, 69(2): 292-302.
[8]
Rocca MA, Valsasina P, Absinta M, et al. Default-mode networks dysfunction and cognitive impairment in progressive MS. Neurology, 2010, 74(16): 1252-1259.
[9]
Rocca MA, Absinta M, Moiola L, et al. Functional and structural connectivity of the motor network in pediatric and adult-onset relapsing-remitting multiple sclerosis. Radiology, 2010, 254(2): 541-550.
[10]
Dogonowski AM, Andersen KW, Madsen KH, et al. Multiple sclerosis impairs regional functional connectivity in the cerebellum. NeuroImage Clin, 2013(4):130-138.
[11]
Liu Y, Liang P, Duan Y, et al. Brain plasticity in relaping-remitting multiple sclerosis: evidence from resting-state fMRI. J Neurol Sci, 2011, 304(1-2): 127.
[12]
李军，张雪雁，姜兴岳，等．联合MR扩散张量成像与波谱分析对胶质母细胞瘤放疗前后的评价．磁共振成像, 2014, 5(2): 88-91.
[13]
Geurts JJ, Bo L, Roosendaal SD, et al. Extensive hippocampal demyelination in multiple sclerosis. J Neuropathol Exp Neurol, 2007, 66(9): 819.
[14]
任庆云，何丽，刘斋，等．轻度认知功能障碍患者后扣带回的磁共振扩散张量成像研究．临床合理用药, 2014, 7(2):23-24.
[15]
吴麟，龚洪翰，周福庆，等. DTI联合ReHo在复发-缓解型多发性硬化患者海马区的研究．临床放射学杂志, 2013, 32(10): 1394-1398.
[16]
Geurs JJ, Bo L, Roosendaal SD, et al. Extensive hippocampal demyelination in multiple sclerosis. J Neuropathol Exp Neurol, 2007, 66(9): 819-827.
[17]
Geurs JJ, Bo L, Pouwels PJ, et al. Cortical lesions in multiple sclerosis: combined postmortem MRI and histopathology. AJNR Am J Neuroradiol, 2005, 26(3): 572-577.
[18]
Rahman MT, Sethi SK, Utriainen DT, et al. A comparative study of magnetic resonance venography techniques for the evaluation of the internal jugular veins in multiple sclerosis patients. Magn Reson Imaging, 2013, 31(10): 1668-1676.

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