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• Clinical Article •
The study of resting state functional magnetic resonance and fiber tracking in multiple sclerosis patients with simple spinal cord involvement
LIU Yi  LI Yong-mei  ZENG Chun  WANG Jing-jie  ZHANG Xiao-hui  ZHANG Xiao-ling  LI Ying 

DOI:10.3969/j.issn.1674-8034.2015.06.004.


[Abstract] Objective: To explore the changes of the brain functional activity and the integrity of brain white matter in multiple sclerosis patients with simple spinal cord involvement (MS-SSCI) by using resting-state functional magnetic resonance imaging (RS-fMRI) and fiber tracking.Materials and Methods: Amplitude of low-frequency fluctuation (ALFF) was compared between 20 MS-SSCI and 20 age-and gender-matched normal controls by using RS-fMRI and the brain regions showing significant difference between groups were defined as the regions of interest (ROI). Fiber tracking was then used to reconstruct the white matter fiber within ROI and then the fractional anisotropy (FA) and the apparent diffusion coefficient (ADC) were compared between the two groups. The relationships between ALFF, FA, ADC of ROI and the expanded disability states scale (EDSS) scores were further explored.Results: Compared with the controls, ALFF decreased in the right hippocampus, but increased in the left middle frontal lobe, left posterior cingulate gyrus and right middle occipital lobe (two-sample t test, after AlphaSim correction, P<0.01, voxel size> 40), MS-SSCI showed significant difference of FA (tright hippocampus=2.099, Pright hippocampus=0.042) and ADC (tright hippocampus=-2.053, Pright hippocampus=0.047)in the right hippocampus; A significant correlation between EDSS scores and ALFF was noted only in the left posterior cingulate gyrus, while no significant correlation between structural parameters and EDSS scores.Conclusion: Our results detected functional and structural abnormalities in MS-SSCI. Moreover, fluctuational abnormalities was closely related to cognitive impairment.
[Keywords] Multiple sclerosis；Spinal cord diseases；Magnetic resonance imaging；Fiber tracking

LIU Yi Department of Radiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

LI Yong-mei* Department of Radiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

ZENG Chun Department of Radiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

WANG Jing-jie Department of Radiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

ZHANG Xiao-hui Department of Radiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

ZHANG Xiao-ling Department of Radiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

LI Ying Department of Radiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

*Correspondence to: Li YM, E-mail: lymzhang70@aliyun.com

Conflicts of interest   None.

Received  2015-03-18
Accepted  2015-04-23
DOI: 10.3969/j.issn.1674-8034.2015.06.004
DOI:10.3969/j.issn.1674-8034.2015.06.004.

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