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• Clinical Article •
Value of using contrast-enhanced magnetic resonance imaging for the evaluation of the short-term effects of radiotherapy for nasopharyngeal cancer
QIN Fang-hui  WANG Yang  SUN Zong-qiong  JIANG Hong  DING Yong-jun  CAI Wei  YUE Jian-guo  XUAN Ying-hua  YAN Gen 

DOI:10.3969/j.issn.1674-8034.2015.06.006.


[Abstract] Objective: To investigate the value of using contrast-enhanced magnetic resonance imaging (MRI) for efficient evaluation before and after radical radiotherapy for nasopharyngeal cancer, and to assess whether the use of visual partitioning analysis for tracking and observing nasopharyngeal cancer staging is sensitive to radiotherapy.Materials and Methods: In total, 50 patients who were preliminarily diagnosed with nasopharyngeal cancer through pathological examinations were retrospectively analyzed, including 9 cases with stage T2, 29 cases with T3, and 12 cases with T4. All cases underwent short-term radiotherapy; T1 weighted imaging, T2 weighted imaging, and contrast-enhanced MRI were performed before and after radiotherapy. visual partitioning analysis was used to comparatively measure the variation in morphology and range of foci, as well as the involvement of surrounding tissues. All the above mentioned data were statistically analyzed using independent sample t-tests.Results: Compared to the conditions before radiotherapy, the tumor foci of 9 cases with parapharyngeal space and/or oropharynx involvement, 29 cases with skull base and/or medial pterygoid involvement, and 7 cases with cranial nerve and/or cavernous sinus and/or paranasal sinus and/or lateral pterygoid involvement showed significant shrinkage or reduction in the size of their cervical lymph nodes, along with non-apparent enhancement or no trend in enhancement (P<0.05). However, among 5 T4 cases, the tumor size non-significantly changed in 4 cases and increased in 1 case (P <0.05); moreover, the intensities of the standardized enhancement of foci did not significantly change.Conclusion: The changes in nasopharyngeal cancer before and after radiotherapy can be sensitively determined through contrast-enhanced MRI, which may thus have good clinical applicability in the effective evaluation of nasopharyngeal cancer. Moreover, the efficacy of radiotherapy fornasopharyngeal cancer may be associated with the pathological staging.
[Keywords] Magnetic resonance imaging；Nasopharyngeal neoplasms；Radiotherapy

QIN Fang-hui Department of Radiology, Affiliated Hospital, Jiangnan University, Wuxi 214062, China

WANG Yang Department of Radiology, Affiliated Hospital, Jiangnan University, Wuxi 214062, China

SUN Zong-qiong Department of Radiology, Affiliated Hospital, Jiangnan University, Wuxi 214062, China

JIANG Hong Department of Radiology, Affiliated Hospital, Jiangnan University, Wuxi 214062, China

DING Yong-jun Department of Radiology, Affiliated Hospital, Jiangnan University, Wuxi 214062, China

CAI Wei Department of Radiology, Affiliated Hospital, Jiangnan University, Wuxi 214062, China

YUE Jian-guo Department of Radiology, Affiliated Hospital, Jiangnan University, Wuxi 214062, China

XUAN Ying-hua Department of Radiology, Affiliated Hospital, Jiangnan University, Wuxi 214062, China

YAN Gen* Department of Radiology, Affiliated Hospital, Jiangnan University, Wuxi 214062, China

*Correspondence to: Yan G, E-mail: gyan@stu.edu.cn

Conflicts of interest   None.

Received  2015-01-13
Accepted  2015-05-04
DOI: 10.3969/j.issn.1674-8034.2015.06.006
DOI:10.3969/j.issn.1674-8034.2015.06.006.

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