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• Clinical Article •
Carotid atherosclerotic plaque composition analysis and classification with 3.0 T MRI
LEI Yun  DING Li  REN Li-xiang  BI Guo-li  LIU Da  GONG Xia-rong  WU Kun-hua 

DOI:10.3969/j.issn.1674-8034.2015.06.007.


[Abstract] Objective: To discuss the capability of 3.0 T high resolution MRI to differentiate carotid atherosclerotic plaque composition and to predict plaque stability.Materials and Methods: Thirty-three consecutive patients with carotid atherosclerotic plaques were scanned using GE 3.0 T MRI. MRI protocols include three-dimensional time-of-flight (3D-TOF), double-inversion recovery T1 weighted image, T2 weighted image, proton density weighted image and carotid artery MRA. Plaque composition and its type were collected and analysed.Results: Total 63 carotid atherosclerotic plaques were found in 33 patients. According to American Heart Association classification, type Ⅰ-Ⅱ plaques accounts for 12.7% of total plaques, type Ⅲ accounts for 27% of total, type Ⅳ-Ⅴ together occupies 19% of them, type Ⅵ with number of 31.8% is the biggest in the group, and type Ⅷ accounts for 9.5%. There was no statistically significant difference for plaque location (Fisher’s exact test: P=0.016). Thirty one stable plaques and 32 unstable plaques were detected of all 63 plaques. There was statistically significant difference between stable plaque group and unstable plaque group in terms of the occurrence rate of lipid rich necrotic core, hemorrhage, thrombosis and integrity of fibrous cap (P<0.05). No significant differences were found for the number of calcification (P>0.05) between the two groups.Conclusion: 3.0 T high resolution MRI has the capability to differentiate and identify plaque compositions between table plaque group and unstable plaque group. It can be an important guidance for treatment option and outcome evaluation.
[Keywords] Carotid arteries；Atherosclerosis；Magnetic resonance imaging

LEI Yun Department of Magnetic Resonance, The First People's Hospital of Yunnan Province, Kunming 650032, China

DING Li Department of Neurology, The First People's Hospital of Yunnan Province, Kunming 650032, China

REN Li-xiang Department of Magnetic Resonance, The First People's Hospital of Yunnan Province, Kunming 650032, China

BI Guo-li Department of Magnetic Resonance, The First People's Hospital of Yunnan Province, Kunming 650032, China

LIU Da Department of Neurology, The First People's Hospital of Yunnan Province, Kunming 650032, China

GONG Xia-rong Department of Magnetic Resonance, The First People's Hospital of Yunnan Province, Kunming 650032, China

WU Kun-hua* Department of Magnetic Resonance, The First People's Hospital of Yunnan Province, Kunming 650032, China

*Correspondence to: Wu KH, E-mail: wukunhua@hotmail.com

Conflicts of interest   None.

Received  2015-03-26
Accepted  2015-05-07
DOI: 10.3969/j.issn.1674-8034.2015.06.007
DOI:10.3969/j.issn.1674-8034.2015.06.007.

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