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• Clinical Article •
Investigation of prostate cancer using intravoxel incoherent motion MR imaging
WAN Hong-yan  BI Yun-qi  YI Yan  TANG Qun-feng  CHEN Jing-wen  FANG Xiang-ming 

Bi Yun-qi are co first authors DOI:10.3969/j.issn.1674-8034.2015.06.010.


[Abstract] Objective: To evaluate the diagnostic value of intravoxel incoherent motion diffusion-weighted imaging for prostate cancer.Materials and Methods: Forty-five patients with prostate cancer and 13 patients without prostate cancer underwent magnetic resonance imaging. DWI was performed by using 8 b values (0, 50, 100, 150, 200, 400, 600, 800 s/mm2). Biexponential fits were applied to diffusion decay curves by special software to calculate pure molecular-based diffusion coefficient (D), pseudo diffusion coefficient of perfusion (D*) and perfusion fraction (f) on the basis of the IVIM model, parameter maps were also calculated for all parameters. Independent samples group t tests were performed to evaluate the statistical significance between cancerous tissue and noncancerous tissue.Results: The D, D* and f values in cancerous tissue were (0.83±0.14) ×10-3 mm2/s, (5.88±1.21)×10-3 mm2/s and (14.3±4.7)%, respectively. The D, D* and f values in noncancerous tissue were (1.30±0.23)× 10-3 mm2/s, (6.25±1.10)×10-3 mm2/s and (15.4±3.8)%, respectively. The D value was significantly (P=0.000) lower in cancerous tissue. D* and f values were not significantly different in both tissues. The area under the receiver operating characteristic-analyses for D value was 0.952, sensitivity and specificity were 100%, 66.7%, respectively.Conclusion: Intravoxel incoherent motion diffusion-weighted imaging may offer additional information about diffusion and perfusion in prostate cancer. Pure molecular-based diffusion coefficient (D) has an important value in diagnosing prostate cancer.
[Keywords] Prostate cancer；Intravoxel incoherent motion；Diffusion weighted imaging

WAN Hong-yan Department of Radiology, Wuxi People’s hospital, Nanjing Medical University, Wuxi 214023, China

BI Yun-qi China people's Liberation Army Military Medical Science Academy of the PLA Ministry of science and technology, Beijing 100850, China

YI Yan China people's Liberation Army Military Medical Science Academy of the PLA Ministry of science and technology, Beijing 100850, China

TANG Qun-feng Department of Radiology, Wuxi People’s hospital, Nanjing Medical University, Wuxi 214023, China

CHEN Jing-wen Department of Radiology, Wuxi People’s hospital, Nanjing Medical University, Wuxi 214023, China

FANG Xiang-ming* Department of Radiology, Wuxi People’s hospital, Nanjing Medical University, Wuxi 214023, China

*Correspondence to: Fang XM, E-mail: drfxm@126.com

Conflicts of interest   None.

Received  2015-03-13
Accepted  2015-04-10
DOI: 10.3969/j.issn.1674-8034.2015.06.010
Bi Yun-qi are co first authors DOI:10.3969/j.issn.1674-8034.2015.06.010.

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