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• Clinical Article •
The value of quantitative evaluation of inflammatory activity by using wrist dynamic contrast-enhanced MRI in rheumatoid arthritis
ZENG Wei-ke  MO Ying-qian  ZHANG Xiang  DUAN Xiao-hui  CHEN Le-feng  MA Jian-da  DAI Lie  SHEN Jun 

DOI:10.3969/j.issn.1674-8034.2015.06.012.


[Abstract] Objective: To investigate the value of quantitative evaluation of inflammatory activity by using wrist dynamic contrast-enhanced MRI (DCE-MRI) in rheumatoid arthritis (RA) patients.Materials and Methods: Twenty patients with clinically and pathologically proved RA underwent wrist DCE-MRI examination, Krenn scoring of synovial inflammatory, clinical scoring of DAS28 and serological examination. Quantitative parameters including the volume transfer constant (Ktrans), rate constant (Kep), extravascular extracellular volume fraction (Ve), plasma volume (Vp) and semi-quantitative parameters including the time to peak (TTP), maximum concentration(Cmax), the area under concentration-time curve (AUC), maximum slope (Slopemax) of wrist synovial lesions were derived from DCE-MRI data. Relationship between quantitative and semi-quantitative parameters and Krenn scores of synovial inflammatory, clinical score of DAS28 and serological results were analyzed by using correlation analysis. Ktrans values between different grades of synovitis were analyzed by using Student t test.Results: The average Ktrans value of 20 patients was (1.27 ± 0.59) ml/min, the average Krenn score was 3.38 ± 1.53, and the average DAS28 score was 4.80 ± 0.94. Pathologically, six patients had high-grade synovitis and eleven patients had low-grade synovitis. Positive correlation was found between Ktrans and Krenn scores, as well as between Ktrans and DAS28 scores (r=0.698, P<0.01; r=0.510, P<0.05 respectively). However, no correlation was found between Kep, Ve, Vp, TTP, Cmax, AUC, Slopemax and Krenn scores, DAS28 scores, serological results (P>0.05). Ktrans values in high-grade synovitis group were higher than these in low-grade synovitis group (t=4.05, P<0.01).Conclusion: Ktrans values derived from DCE-MRI can be used to reflect the clinical and pathological inflammatory activity of RA.
[Keywords] Magnetic resonance imaging；Dynamic contrast-enhancement；Arthritis, Rheumatoid；Wrist Joint

ZENG Wei-ke Department of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University. Guangzhou 510120, China

MO Ying-qian Department of rheumatology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University. Guangzhou 510120, China

ZHANG Xiang Department of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University. Guangzhou 510120, China

DUAN Xiao-hui Department of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University. Guangzhou 510120, China

CHEN Le-feng Department of rheumatology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University. Guangzhou 510120, China

MA Jian-da Department of rheumatology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University. Guangzhou 510120, China

DAI Lie Department of rheumatology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University. Guangzhou 510120, China

SHEN Jun* Department of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University. Guangzhou 510120, China

*Correspondence to: Shen J, E-mail: shenjun@mail.sysu.edu.cn

Conflicts of interest   None.

Received  2015-04-13
Accepted  2015-05-05
DOI: 10.3969/j.issn.1674-8034.2015.06.012
DOI:10.3969/j.issn.1674-8034.2015.06.012.

[1]
Krabben A, Stomp W, van Nies JA, et al. MRI-detected subclinical joint inflammation is associated with radiographic progression. Ann Rheum Dis, 2014, 73(11): 2034-2037.
[2]
Palosaari K, Vuotila J, Takalo R, et al. Cotrast-enhanced dynamic and static MRI correlates with quantitative 99Tcm-labelled nanocolloid scintigraphy. Study of early rheumatoid arthritis patients. Rheumatology(Oxford), 2004, 43(11): 1364-1373.
[3]
Bird P, Lassere M, Shnier R, et al. Computerized measurement of magnetic resonance imaging erosion volumes in patients with rheumatoid arthritis: a comparison with existing magnetic resonance imaging scoring systems and standard clinical outcome measures. Arthritis Rheum, 2003, 48(3): 614-624.
[4]
Yun TJ, Park CK, Kim TM, et al. Glioblastoma Treated with Concurrent Radiation Therapy and Temozolomide Chemotherapy: Differentiation of True Progression from Pseudoprogression with Quantitative Dynamic Contrast-enhanced MR Imaging. Radiology, 2014, DOI: , 10.1148/radiol.14132632.
[5]
Murase K. Efficient method for calculating kinetic parameters using T1-weighted dynamic contrast-enhanced magnetic resonance imaging. Magn Reson Med, 2004, 51(4): 858-862.
[6]
Anderson J, Caplan L, Yazdany J, et al. Rheumatoid arthritis diseaseactivity measures:American College of Rheumatology recommendations for use in clinical practice. Arthritis Care & Research, 2012, 64(5): 640-647.
[7]
Prvoo ML, van' t Hof MA, Kuper HH, et al. Modified disease activity scores that included twenty-eight-joint counts. Arthritis Rheum, 1995, 38(1): 44-48.
[8]
Kraan MC, Reece RJ, Smeets TJ, et al. Comparison of Synovial Tissues From the Knee Joints and the Small Joints of Rheumatoid Arthritis Patients. Arthritis Rheum, 2002, 46(8): 2034-2038.
[9]
Krenn V, Morawietz L, Burmester GR. Synovitis score: discrimination between chronic low-grade and high-grade synovitis. Histopathology, 2006, 49(4): 358-364.
[10]
陈悦熙，张芳，沈君.类风湿关节炎手腕关节MRI弥散加权成像与滑膜病理相关性分析．中华临床医师杂志（电子版）, 2012, 6(22): 7270-7274.
[11]
霍蕾，闫铄，王健，等．定量动态增强MRI对评价慢性期甲状腺相关眼病眼外肌受累的价值．磁共振成像, 2014, 5(1): 30-34.
[12]
Tofts PS, Brix G, Buckley DL, et al. Estimating kinetic parameters from dynamic contrast-enhanced T1-weighted MRI of a diffusable tracer:standardized quantities and symbols. J Magn Reson Imaging, 1999, 10(3): 223-232.
[13]
Brix G, Semmler W, Port R, et al. Pharmacokinetic parameters in CNS Gd-DTPA enhanced MR imaging. J Comput Assist Tomogr, 1991, 15(4): 621-628.
[14]
Port RE, Knopp MV, Hoffmann U, et al. Multicompartment analysis of gadolinium chelate kinetics:blood-tissue exchange in mammary tumors as monitored by dynamic MR imaging. J Magn Reson Imaging, 1999, 10(3): 233-241.
[15]
李春媚，陈敏，李飒英，等. 3.0 T MR动态增强扫描定量分析诊断前列腺癌的初步研究．中华放射学杂志, 2011, 45(1): 50-54.
[16]
李瑞敏，顾雅佳，毛健，等．定量动态增强MRI鉴别乳腺良恶性病变的研究．中华放射学杂志, 2011, 45(2): 164-169.
[17]
白雪冬，孙夕林，王丹，等．动态对比增强MRI在鉴别胶质瘤复发及放射性脑损伤中的应用．磁共振成像, 2014, 5(1): 1-6.
[18]
陈基明，翟建，张峥嵘，等．动态增强MRI对早期类风湿性关节炎的诊断价值.临床放射学杂志, 2014, 33(3): 415-419.
[19]
傅丽晖，李晖，王波，等．腕关节3D LAVA动态增强在判断类风湿性关节炎疾病进程的价值研究．中国临床医学影像杂志, 2014, 25(2): 113-119.

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