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• Clinical Article •
The value of quantitative evaluation of inflammatory activity by using wrist dynamic contrast-enhanced MRI in rheumatoid arthritis
ZENG Wei-ke  MO Ying-qian  ZHANG Xiang  DUAN Xiao-hui  CHEN Le-feng  MA Jian-da  DAI Lie  SHEN Jun 

DOI:10.3969/j.issn.1674-8034.2015.06.012.


[Abstract] Objective: To investigate the value of quantitative evaluation of inflammatory activity by using wrist dynamic contrast-enhanced MRI (DCE-MRI) in rheumatoid arthritis (RA) patients.Materials and Methods: Twenty patients with clinically and pathologically proved RA underwent wrist DCE-MRI examination, Krenn scoring of synovial inflammatory, clinical scoring of DAS28 and serological examination. Quantitative parameters including the volume transfer constant (Ktrans), rate constant (Kep), extravascular extracellular volume fraction (Ve), plasma volume (Vp) and semi-quantitative parameters including the time to peak (TTP), maximum concentration(Cmax), the area under concentration-time curve (AUC), maximum slope (Slopemax) of wrist synovial lesions were derived from DCE-MRI data. Relationship between quantitative and semi-quantitative parameters and Krenn scores of synovial inflammatory, clinical score of DAS28 and serological results were analyzed by using correlation analysis. Ktrans values between different grades of synovitis were analyzed by using Student t test.Results: The average Ktrans value of 20 patients was (1.27 ± 0.59) ml/min, the average Krenn score was 3.38 ± 1.53, and the average DAS28 score was 4.80 ± 0.94. Pathologically, six patients had high-grade synovitis and eleven patients had low-grade synovitis. Positive correlation was found between Ktrans and Krenn scores, as well as between Ktrans and DAS28 scores (r=0.698, P<0.01; r=0.510, P<0.05 respectively). However, no correlation was found between Kep, Ve, Vp, TTP, Cmax, AUC, Slopemax and Krenn scores, DAS28 scores, serological results (P>0.05). Ktrans values in high-grade synovitis group were higher than these in low-grade synovitis group (t=4.05, P<0.01).Conclusion: Ktrans values derived from DCE-MRI can be used to reflect the clinical and pathological inflammatory activity of RA.
[Keywords] Magnetic resonance imaging；Dynamic contrast-enhancement；Arthritis, Rheumatoid；Wrist Joint

ZENG Wei-ke Department of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University. Guangzhou 510120, China

MO Ying-qian Department of rheumatology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University. Guangzhou 510120, China

ZHANG Xiang Department of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University. Guangzhou 510120, China

DUAN Xiao-hui Department of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University. Guangzhou 510120, China

CHEN Le-feng Department of rheumatology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University. Guangzhou 510120, China

MA Jian-da Department of rheumatology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University. Guangzhou 510120, China

DAI Lie Department of rheumatology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University. Guangzhou 510120, China

SHEN Jun* Department of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University. Guangzhou 510120, China

*Correspondence to: Shen J, E-mail: shenjun@mail.sysu.edu.cn

Conflicts of interest   None.

Received  2015-04-13
Accepted  2015-05-05
DOI: 10.3969/j.issn.1674-8034.2015.06.012
DOI:10.3969/j.issn.1674-8034.2015.06.012.

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