Share：
Share this content in WeChat
X
[Chinese][PDF]86897
• Original Article •
Aassessment of diffusion-weighted imaging in staging liver fibrosis in rabbits
DENG Qian-hua  RUAN Ji-yin  JIANG Jin-zhao  FENG Fei  XIE Jia-jun  ZOU Li-qiu 

DOI:10.3969/j.issn.1674-8034.2015.06.014.


[Abstract] Objective: To evaluate the accuracy of apparent diffusion coefficient(ADC) correlates on staging liver fibrosis.Materials and Methods: The study consisted of three groups: HF group (n=32), control group (n=15) and supplemental group (n=12). Rabbits from control and HF group underwent conventional MRI and DWI scan and the liver ADC values were measured. In HF group, eight rabbits randomly underwent MRI examinations at 4, 5, 6, 10 weeks after CCl4 administration. The correlation between ADC values and HF stages was assessed. The diagnostic performance of DWI for staging HF was compared using the receiver operating characteristic curve analysis on the basis of the histopathologic analysis of HF.Results: Significant differences of ADC values were present among HF stages (F=5.344, P<0.005). The ADC values were correlated with the HF stages (r=-0.630, P<0.001). Sensitivity, specificity, positive (PPV) and negative predictive values (NPV) were for ≥S1: 75.00%, 55.56%, 85.70%, 38.50%, respectively; for ≥S2: 79.2%, 58.8%, 73.1%, 66.7%; for ≥S3: 87.5%, 80.0%, 73.70%, 90.9%; for S4: 87.50%, 66.67%, 38.90%, 95.7%.Conclusion: DWI can offer important assistance in staging HF as a non-invasive technique.
[Keywords] Liver fibrosis；Liver cirrhosis；Magnetic resonance imaging, diffusion weighted；Rabbits

DENG Qian-hua Department of medical imaging, Peking University Shenzhen Hospital, Shenzhen 518036, China

RUAN Ji-yin Department of medical imaging, Peking University Shenzhen Hospital, Shenzhen 518036, China

JIANG Jin-zhao Department of Radiology, the University of Hong Kong-Shenzhen Hospital, Shenzhen 518053, China

FENG Fei Department of medical imaging, Peking University Shenzhen Hospital, Shenzhen 518036, China

XIE Jia-jun Department of medical imaging, Peking University Shenzhen Hospital, Shenzhen 518036, China

ZOU Li-qiu* Department of medical imaging, Peking University Shenzhen Hospital, Shenzhen 518036, China

*Correspondence to: Zou LQ, E-mail: baszzlq@163.com

Conflicts of interest   None.

Received  2015-02-12
Accepted  2015-05-04
DOI: 10.3969/j.issn.1674-8034.2015.06.014
DOI:10.3969/j.issn.1674-8034.2015.06.014.

[1]
Kanwal F, Hoang T, Kramer JR, et al. Increasing prevalence of HCC and cirrhosis in patients with chronic hepatitis C virus infection. Gastroenterology, 2011, 140(4): 1182-1188.
[2]
Talwalkar JA, Yin M, Fidler JL, et al. Magnetic resonance imaging of hepatic fibrosis: emerging clinical applications. Hepatology, 2008, 47(1): 332-342.
[3]
Aubé C, Racineux P X, Lebigot J, et al. Diagnosis and quantification of hepatic fibrosis with diffusion weighted MR imaging:preliminary results. J Radiol, 2004, 85(3): 301-306.
[4]
Lewin M, Poujol-Robert A, Boelle PY, et al. Diffusion-weighted magnetic resonance imaging for the assessment of fibrosis in chronic hepatitis C. Hepatology, 2007, 46(3): 658-665.
[5]
Annet L, Peeters F, Abarca-Quinones J, et al. Assessment of diffusion weighted MR imaging in liver fibrosis. J Magn Reson Imaging, 2007, 25(1): 122-128.
[6]
Martínez SM, Crespo G, Navasa M, et al. Noninvasive assessment of liver fibrosis. Hepatology, 2011, 53(1): 325-335.
[7]
郭启勇，石喻．磁共振成像在肝病的应用及进展．磁共振成像, 2014, 5(S1): 10-14.
[8]
Taouli B, Tolia AJ, Losada M, et al. Diffusion-weighted MRI for quantification of liver fibrosis: preliminary experience. AJR Am J Roentgenol, 2007, 189(4): 799-806.
[9]
Patel J, Sigmund EE, Rusinek H, et al. Diagnosis of cirrhosis with intravoxel incoherent motion diffusion MRI and dynamic contrast-enhanced MRI alone and in combination: preliminary experience. J Magn Reson Imaging, 2010, 31(3): 589-600.
[10]
Pandharipande PV, Krinsky GA, Rusinek H, et al. Perfusion imaging of the liver: current challenges and future goals. Radiology, 2005, 234(3): 661-673.
[11]
Hagiwara M, Rusinek H, Lee VS, et al. Advanced liver fibrosis: diagnosis with 3D whole liver perfusion MR imaging initial experience. Radiology, 2008, 246(3): 926-934.
[12]
Ichikawa T, Haradome H, Hachiya J, et al. Diffusion-weighted MR imaging with single-shot echo-planar imaging in the upper abdomen: preliminary clinical experience in 61 patients. Abdom Imaging, 1999, 24(5): 456-461.
[13]
Ozkurt H, Keskiner F, Karatag O, et al. Diffusion Weighted MRI for Hepatic Fibrosis: Impact of b-Value. Iran J Radiol, 2014, 11(1): 3555.
[14]
刘再毅，陈鑫，颜丽芬，等. b值对肝脏磁共振扩散加权成像ADC值及其可重复性和影响．中国医学影像学杂志, 2013, 5(16): 370-373.
[15]
黄勇跃，金军，汤小莉，等．扩散加权成像和瞬时弹性成像在肝纤维化诊断价值中的对比研究.磁共振成像, 2013, 4(4): 261-265.
[16]
Pasquinelli F, Belli G, Mazzoni LN, et al. MR-diffusion imaging in assessing chronic liver diseases: does a clinical role exist?. Radiol med, 2012, 117(2): 242-253.

PREV The value of FIESTA sequence in the diagnostis of inferior vena cava lesions with Budd-Chiari syndrome
NEXT The preliminary study of virtual magnetic resonance imaging in case of the main field inhomogeneity
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn