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• Original Article •
Aassessment of diffusion-weighted imaging in staging liver fibrosis in rabbits
DENG Qian-hua  RUAN Ji-yin  JIANG Jin-zhao  FENG Fei  XIE Jia-jun  ZOU Li-qiu 

DOI:10.3969/j.issn.1674-8034.2015.06.014.


[Abstract] Objective: To evaluate the accuracy of apparent diffusion coefficient(ADC) correlates on staging liver fibrosis.Materials and Methods: The study consisted of three groups: HF group (n=32), control group (n=15) and supplemental group (n=12). Rabbits from control and HF group underwent conventional MRI and DWI scan and the liver ADC values were measured. In HF group, eight rabbits randomly underwent MRI examinations at 4, 5, 6, 10 weeks after CCl4 administration. The correlation between ADC values and HF stages was assessed. The diagnostic performance of DWI for staging HF was compared using the receiver operating characteristic curve analysis on the basis of the histopathologic analysis of HF.Results: Significant differences of ADC values were present among HF stages (F=5.344, P<0.005). The ADC values were correlated with the HF stages (r=-0.630, P<0.001). Sensitivity, specificity, positive (PPV) and negative predictive values (NPV) were for ≥S1: 75.00%, 55.56%, 85.70%, 38.50%, respectively; for ≥S2: 79.2%, 58.8%, 73.1%, 66.7%; for ≥S3: 87.5%, 80.0%, 73.70%, 90.9%; for S4: 87.50%, 66.67%, 38.90%, 95.7%.Conclusion: DWI can offer important assistance in staging HF as a non-invasive technique.
[Keywords] Liver fibrosis；Liver cirrhosis；Magnetic resonance imaging, diffusion weighted；Rabbits

DENG Qian-hua Department of medical imaging, Peking University Shenzhen Hospital, Shenzhen 518036, China

RUAN Ji-yin Department of medical imaging, Peking University Shenzhen Hospital, Shenzhen 518036, China

JIANG Jin-zhao Department of Radiology, the University of Hong Kong-Shenzhen Hospital, Shenzhen 518053, China

FENG Fei Department of medical imaging, Peking University Shenzhen Hospital, Shenzhen 518036, China

XIE Jia-jun Department of medical imaging, Peking University Shenzhen Hospital, Shenzhen 518036, China

ZOU Li-qiu* Department of medical imaging, Peking University Shenzhen Hospital, Shenzhen 518036, China

*Correspondence to: Zou LQ, E-mail: baszzlq@163.com

Conflicts of interest   None.

Received  2015-02-12
Accepted  2015-05-04
DOI: 10.3969/j.issn.1674-8034.2015.06.014
DOI:10.3969/j.issn.1674-8034.2015.06.014.

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