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• Clinical Article •
Metabolic changes of striatum and substantia nigra in patients with early Parkinson's disease demonstrated by 1H-MRS
FANG Xue-wen  HU Tao  WU Yu-hua  LI Jian-ming  ZHANG An  HU Yan-xing  ZHOU Guo-hua  SHEN Jun 

DOI:10.3969/j.issn.1674-8034.2015.07.001.


[Abstract] Objective: To investigate whether 1H-MRS can be used to demonstrate the metabolic changes in striatum and substantia nigra for early Parkinson’s disease (PD).Materials and Methods: Totally, 44 patients with early Parkinson’s disease having bilateral symptoms but without dementia were enrolled. Thirty-two age and sex-matched volunteers were included as normal controls. 1H-MRS using singlevoxel PRESS for the striatum and multiple-voxel PRESS for the substantia nigra were performed. MRS data were successfully obtained from the striatum in 33 patients and the substantia nigra in 32 patients, and respectively from 31 and 28 volunteers. The metabolite contents, including N-acetylaspartete (NAA), Choline (Cho), Creatinine (Cr) and their relative ratios were analyzed and compared.Results: No significant differences were found for each ratio of metabolite contents between right and left in striatum and substantia nigra either in the patients or in the controls (P>0.05). The NAA/Cr ratio of the striatum was lower in the PD patients than that in controls (P<0.05), but no significant differences were found in other ratios (P>0.05). In the substantia nigra, there were no significant differences for all metabolite content ratios between the two groups (P>0.05).Conclusions: 1H-MRS can be used to detect the metabolic abnormality in striatum for early PD with bilateral symptoms without dementia, which is helpful for the early diagnosis of PD.
[Keywords] Parkinson disease；Magnetic resonance spectroscopy；Substantia nigra；Corpus striatum

FANG Xue-wen Department of Radiology, Dongguan People's Hospital, Dongguan 523018, China

HU Tao Department of Radiology, Dongguan People's Hospital, Dongguan 523018, China

WU Yu-hua Department of Endocrinology, Dongguan People's Hospital, Dongguan 523018, China

LI Jian-ming Department of Radiology, Dongguan People's Hospital, Dongguan 523018, China

ZHANG An Department of Radiology, Dongguan People's Hospital, Dongguan 523018, China

HU Yan-xing Department of Radiology, Dongguan People's Hospital, Dongguan 523018, China

ZHOU Guo-hua Department of Radiology, Dongguan People's Hospital, Dongguan 523018, China

SHEN Jun* Department of Radiology, Dongguan People's Hospital, Dongguan 523018, China

*Correspondence to: Shen J, E-mail: shenjun@mail.sysu.edu.cn

Conflicts of interest   None.

Received  2015-01-30
Accepted  2015-03-26
DOI: 10.3969/j.issn.1674-8034.2015.07.001
DOI:10.3969/j.issn.1674-8034.2015.07.001.

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