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• Clinical Article •
The value of intravoxel incoherent motion model of diffusion weighted imaging in differentiating benign from malignant breast lesions
CHE Shu-nan  CUI Xiao-lin  LI Jing  OUYANG Han  ZHOU Chun-wu 

DOI:10.3969/j.issn.1674-8034.2015.07.006.


[Abstract] Objective: To investigate the diagnostic value of parameters derived from diffusion-weighted imaging intravoxel incoherent motion (IVIM) model for benign and malignant breast lesions, and compare these parameters with that of monoexponential model and dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI).Materials and Methods: Seventy cases (23 cases of benign lesions in total 24, 47 cases of malignant lesions in total 48) of breast disease with breast MRI examination in our hospital were collected. All of them were examined with multiple-b-value diffusion-weighted imaging (DWI) and DCE-MRI scans. GE AW4.4 workstation was used to calculate the value of ADC, ADCstandard, D, D*, f, and to generate time-signal intensity curve (TIC). All parameters between benign and malignant breast lesions were compared by Mann-Whitney U test. The diagnostic performance of different parameters was evaluated by receiver operating characteristic curve (ROC curve) analysis.Results: The ADC, ADCstandard, D, f value of malignant lesions were (1.01±0.18)×10-3 mm2/s, (1.10±0.18)×10-3 mm2/s, (0.86±0.16)×10-3 mm2/s, (25.50±9.23) % respectively, benign lesions were (1.42±0.29)×10-3 mm2/s, (1.53±0.27)×10-3 mm2/s, (1.28±0.26)×10-3 mm2/s, (15.98±3.68) %. There were statistically significant differences between these parameters (P<0.001). With ROC curve analysis for each parameter value, the area under the curve (AUC) of D value was 0.932 which was the highest one, and corresponding diagnostic sensitivity and specificity were 89.6% and 91.7% while taking the optimal threshold of 1.03×10-3 mm2/s. AUC value can be increased to 0.974 by combining D with f value, and the corresponding diagnostic sensitivity and specificity were 85.4% and 100% respectively.Conclusions: The ADCstandard, D and f value from the IVIM model can be used to distinguish benign from malignant breast lesions. Associated with D and f value can obtain better diagnostic performance than the ADC value and the TIC.
[Keywords] Diffusion magnetic resonance imaging；Breast neoplasms；Intravoxel incoherent motion

CHE Shu-nan Department of Diagnostic Radiology, Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021, China

CUI Xiao-lin Department of Diagnostic Radiology, Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021, China

LI Jing Department of Diagnostic Radiology, Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021, China

OUYANG Han Department of Diagnostic Radiology, Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021, China

ZHOU Chun-wu* Department of Diagnostic Radiology, Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021, China

*Correspondence to: Zhou CW, E-mail: cjr.zhouchunwu@vip.163.com

Conflicts of interest   None.

Received  2015-04-27
Accepted  2015-06-05
DOI: 10.3969/j.issn.1674-8034.2015.07.006
DOI:10.3969/j.issn.1674-8034.2015.07.006.

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