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• Clinical Article •
Correlation of MR apparent diffusion coefficient value with HER-2 expression in non-mass-like breast carcinoma
XU Mao-lin  SU Dan-ke  XIE Dong  JIN Guan-qiao  WANG Zheng  HUANG Xiang-yang  LI Fang  ZHANG Wei 

DOI:10.3969/j.issn.1674-8034.2015.07.007.


[Abstract] Objective: To investigate the association of MR apparent diffusion coefficient (ADC) value with HER-2 expression in non-mass-like breast carcinoma.Materials and Methods: Seventy-three cases diagnosed as breast cancers by pathologic examination underwent magnetic resonance prior to surgery. All cases performed non-mass-like enhancement in dynamic contrast-enhanced MR imaging. The expression of HER-2 in tumor tissue were assayed by immunohistochemical (IHC) staining and Fluorescence in situ hybridization (FISH). ADC value was calculated using two b factors (b=0, 800 s/mm2). t test and Spearman rank correlation were used toevaluate correlations between ADC value with HER-2 expression. ROC curve was applied to get the best threshold of ADC value,which was to judge HER-2 expression.Results: The ADC value in HER-2 positive and negtive expression group was (1.028±0.171)×10-3 mm2/s and (0.931±0.176)×10-3 mm2/s, respectively. The ADC value in the positive expression group was significantly higher (t=2.212, P=0.030). ADC value had positive correlation with the positive expression of HER-2(r=0.294, P=0.012). The best threshold of ADC value to judge HER-2 expression was 0.977×10-3 mm2/s by ROC curve, while the sensitivity and specificity were 70.8% and 67.3%, respectively.Conclusions: ADC value may have positive correlation with the expression of HER-2 in non-mass-like breast carcinoma, and draw up the treatment plan and prognosis evaluation for patients.
[Keywords] non-mass-like enhancement；Breast carcinoma；ADC value；HER-2

XU Mao-lin Department of Radiology, the Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, China

SU Dan-ke* Department of Radiology, the Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, China

XIE Dong Department of Radiology, the Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, China

JIN Guan-qiao Department of Radiology, the Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, China

WANG Zheng Department of Radiology, the Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, China

HUANG Xiang-yang Department of Radiology, the Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, China

LI Fang Department of Radiology, the Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, China

ZHANG Wei Department of Radiology, the Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, China

*Correspondence to: Su DK, E-mail: sudanke33@sina.com

Conflicts of interest   None.

Received  2015-05-15
Accepted  2015-06-24
DOI: 10.3969/j.issn.1674-8034.2015.07.007
DOI:10.3969/j.issn.1674-8034.2015.07.007.

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