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• Clinical Article •
Assessment of renal injury in diabetic nephropathy using blood oxygenation level-dependent MRI
JIANG Zhen-xing  WANG Yu  DING Jiu-le  ZHOU Hua  DI Jia  WAN Hui  CHEN Jie  XING Wei 

DOI:10.3969/j.issn.1674-8034.2015.07.009.


[Abstract] Objective: To explore the clinical application of blood oxygenation level-dependent MRI for the assessment of diabetic nephropathy (DN).Materials and Methods: Eleven cases of healthy volunteers (control group), 19 cases with early-stage DN and 15 cases with moderate-to severe-stage (MS-stage) DN were scanned by BOLD-MRI. The three parameters, including cortical R2* value (CR2*), medullary R2* value (MR2*) and R2* ratio of the medullary R2* value to cortical R2* value (MCR), were measured and calculated.Results: The MR2* was higher than CR2* in each group (P<0.01). MR2* was significantly different between the normal control group and early-stage DN group (P<0.01), and area under receiver operating characteristic curve (AUC) was 0.940. Both CR2* and MCR were significantly different between the early-stage and MS-stage DN groups (P<0.01). AUCs were 0.884 and 0.764, respectively, and there was no significant difference between them (P>0.05). CR2* correlated inversely with eGFR (P<0.01), while MCR correlated positively (P<0.05). The three parameters showed no significant correlation with HbA1c (P>0.05).Conclusions: BOLD-MRI could reflect renal injury in diabetic nephropathy and had a potential value for clinical application.
[Keywords] Diabetic nephropathies；Magnetic resonance imaging

JIANG Zhen-xing Department of Radiology, Third Affiliated Hospital of Soochow University, Changzhou 213003, China

WANG Yu Department of Radiology, Third Affiliated Hospital of Soochow University, Changzhou 213003, China

DING Jiu-le Department of Radiology, Third Affiliated Hospital of Soochow University, Changzhou 213003, China

ZHOU Hua Department of Nephrology, Third Affiliated Hospital of Soochow University, Changzhou 213003, China

DI Jia Department of Nephrology, Third Affiliated Hospital of Soochow University, Changzhou 213003, China

WAN Hui Department of Endocrinology, Third Affiliated Hospital of Soochow University, Changzhou 213003, China

CHEN Jie Department of Radiology, Third Affiliated Hospital of Soochow University, Changzhou 213003, China

XING Wei* Department of Radiology, Third Affiliated Hospital of Soochow University, Changzhou 213003, China

*Correspondence to Xing W, E-mail: suzhxingwei@126.com

Conflicts of interest   None.

Received  2015-04-29
Accepted  2015-06-08
DOI: 10.3969/j.issn.1674-8034.2015.07.009
DOI:10.3969/j.issn.1674-8034.2015.07.009.

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