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• Technical Article •
Feasibility of multiple-echo GRE with parameters optimized protocol at 3.0 T MRI
HUANG Hai-bo  ZHOU Ya-li  LI Zhi-zhong  GUAN Jun  QIN Ming 

DOI:10.3969/j.issn.1674-8034.2015.07.010.


[Abstract] Objective: To explore the feasibility of 12-echo GRE with parameter optimized protocol at 3.0 T MRI by shortening minimum TE (TEmin) and scan time (ST).Materials and Methods: A MR special model which includes fifteen vials containing 0—3.2 mM manganese chloride in hydrochloric acid solution, 45 volunteer livers of 10 severe and 35 non-severe iron-overloaded patients were included in the study. 12-echo GRE sequence with parameter optimized at 3.0 Tesla unit was performed in our study and conventional protocol was executed in control group. T2* or R2* were quantified by a well-trained physician using a CMR tools or combining with EXCEL after MRI, TEmin and ST obtained from these two protocols were recorded respectively as well. Difference of values in T2*, TEmin and ST between the two groups were analyzed with SPSS 16.0 (Paired-Sample t test or Two Related Sample Test). P<0.05 has statistic significance. The correlation between R2* and phantom concentration (PhC) was analyzed by two-correlative-variable and curve-fitting.Results: Statistic differences were found for TEmin and ST value between the two groups (P=0.000), TEmin and ST value obtained from study protocol were (0.62±0.02) ms and (9.3±0.8) s, reduced by 53.0%, 45.0% comparing to control groups, respectively. For phantom and non-severe iron deposit livers, no statistic differences were found for T2* value between the two groups (Pphantom/liver=0.814/0.201). However, for severe iron deposit group, there was statistic difference between these two groups (P=0.001), also quantitative reliability of T2* value from study protocol was much better than control sequence. No statistic difference was found for T2* value among study sequence scan on phantoms, protocol repeating and next month scan (P=0.584). Phantom R2* was linearly correlated with its PhC (r=0.986, P=0.000). Through the regressions procedure, a slope of 7.008 and an intercept of 0.036 were found.Conclusions: Within a certain range of iron deposits, 12-echo GRE protocol with parameters optimized is feasible at 3.0 T MRI for both phantoms and in vivo livers. For severe hepatic iron deposit, measurement by 3.0 T MRI showed a better reliability.
[Keywords] Magnetic resonance imaging；Diagnostic techniques and procedures

HUANG Hai-bo* Department of Medical Imaging,303rd Hospital of the PLA, Nanning 530021, China

ZHOU Ya-li Department of Haematology, 303rd Hospital of the PLA, Nanning 530021, China

LI Zhi-zhong Guangxi Healthy professional technology college, Nanning 530021, China

GUAN Jun Department of Medical Imaging,303rd Hospital of the PLA, Nanning 530021, China

QIN Ming Department of Medical Imaging,303rd Hospital of the PLA, Nanning 530021, China

*Correspondence to: Huang HB, E-mail: jackie000528@163.com

Conflicts of interest   None.

Received  2015-05-03
Accepted  2015-06-19
DOI: 10.3969/j.issn.1674-8034.2015.07.010
DOI:10.3969/j.issn.1674-8034.2015.07.010.

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