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• DCE-MRI Quantitative Technique Subject •
An expectable wave of clinical studies using quantitative dynamic contrast-enhanced MR imaging
SHEN Jun 

DOI:10.3969/j.issn.1674-8034.2015.08.001.


[Abstract] Quantitative dynamic contrast-enhanced MR imaging (dynamic contrast-enhanced MRI, DCE-MRI) using fast T1-weighted imaging is considered as a functional tool to non-invasively assess the microcirculation features of normal or diseased tissues. It can be used to assess tissue perfusion and microvessel permeability by means of qualitative, semi-quantitative and quantitative method. With inclusion of arterial input function and tissue concentration of contrast agents used, quantitative DCE-MRI is superior to either qualitative or semi-quantitative method with respect to accurate evaluation of tissue perfusion and microvessel permeability; and can avoid inconsistent analysis results between different researchers caused by individual scanning protocols used. Thus quantitative DCE-MRI is not only favorable to achieve an early diagnosis and improve accuracy of the differential diagnosis of various disease entities, but also helpful for implementation of a multicenter randomized control clinical trials to obtain evidence medicine data. To date, some obstacles are still present in DCE-MRI, such as the standardization of scanning protocols and data computation, particularly the application of appropriate hemodynamic models. Advanced software specialized designed for quantitative DCE-MRI can provide a standard and convenient platform for data analysis. With the help of such favorable platform, the progress of clinical application of DCE-MRI would be promoted and its application field would be extended.
[Keywords] Magnetic resonance imaging；Dynamic contrast-enhancement；Quantitative analysis

SHEN Jun* Department of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University. Guangzhou 510120, China

*Correspondence to: Shen J, E-mail: shenjun@mail.sysu.edu.cn

Conflicts of interest   None.

Received  2015-06-16
Accepted  2015-06-30
DOI: 10.3969/j.issn.1674-8034.2015.08.001
DOI:10.3969/j.issn.1674-8034.2015.08.001.

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