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• DCE-MRI Quantitative Technique Subject •
Dynamic contrast-enhanced MRI in the differential diagnosis of high grade glioma, low grade glioma and meningioma
ZHANG Wei  NIU Lei  MA Min-ge  ZHOU Hao  LIU Xue-jun  FENG Wei-hua  SUI Qing-lan 

DOI:10.3969/j.issn.1674-8034.2015.08.002.


[Abstract] Objective: Through undergoing dynamic contrast-enhanced MRI (dynamic contrast-enhanced MRI, DCE-MRI) before operation to provide quantitative basis for the differential diagnosis of the three kinds of tumors.Materials and Methods: Nineteen cases of gliomas (7 with low grade, 12 with high grade) and 19 cases of meningiomas (13 with benign, 6 with malignant or anaplastic) were enrolled. The pharmacokinetic model of Extended Tofts Linear was used to calculate the datas, the tissue enhancement-time curve and pharmacokinetic parameters (volume transfer constant, Ktrans, extracellular extravascular volume fraction, Ve; and blood plasma fraction, Vp) of the lesion, solid components were obtained. Ktrans value, Ve value and Vp value were compared to judge whether there were significant differences between the three kinds of tumors.Results: The values of Ktrans and Ve in high grade glioma (HGG) were significantly higher than the low grade glioma(LGG) (P<0.05); Vp values of high grade glioma were slightly higher than the low grade glioma, but the difference was not statistically significant; The values of Ktrans and Ve in meningiomas were significantly higher than the low grade gliomas (P<0.05), but the difference of Vp values were not statistically significant; the differences of Ktrans, Ve, Vp of gliomas and meningiomas were not statistically significant (P>0.05).Conclusion: DCE-MRI can effectively distinguish low grade glioma from high grade glioma and low grade glioma from meningioma, At the same time, DCE-MRI improves the diagnosis accuracy of glioma and invasive meningioma through the quantitative analysis .
[Keywords] Magnetic resonance imaging；Dynamic contrast-enhancement；Glioma；Meningioma；Pharmacokinetic parameters

ZHANG Wei Department of Radiology, The Afflilated Hospital of Qingdao University, Qingdao 266000, China

NIU Lei Department of Radiology, The Afflilated Hospital of Qingdao University, Qingdao 266000, China

MA Min-ge Department of Radiology, The Afflilated Hospital of Qingdao University, Qingdao 266000, China

ZHOU Hao Department of Radiology, The Afflilated Hospital of Qingdao University, Qingdao 266000, China

LIU Xue-jun Department of Radiology, The Afflilated Hospital of Qingdao University, Qingdao 266000, China

FENG Wei-hua Department of Radiology, The Afflilated Hospital of Qingdao University, Qingdao 266000, China

SUI Qing-lan* Department of Radiology, The Afflilated Hospital of Qingdao University, Qingdao 266000, China

*Correspondence to: Sui QL, E-mail: suiql@163.com

Conflicts of interest   None.

Received  2015-05-31
Accepted  2015-06-12
DOI: 10.3969/j.issn.1674-8034.2015.08.002
DOI:10.3969/j.issn.1674-8034.2015.08.002.

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