Share：
Share this content in WeChat
X
[Chinese][PDF]817155
• DCE-MRI Quantitative Technique Subject •
The reproducibility study of the pharmacokinetic model extended tofts linear of the dynamic contrast-enhanced MRI in brain glioma
JIA Long-wei  NIU Lei  MA Wen-shuai  LIU Xue-jun  FENG Wei-hua  SUI Qing-lan 

DOI:10.3969/j.issn.1674-8034.2015.08.003.


[Abstract] Objective: Through repeatedly measuring the dynamic contrast-enhanced MRI (DCE-MRI) pharmacokinetic parameters-volume transfer constant, Ktrans; extracellular extravascular volume fraction, Ve; and blood plasma fraction, Vp of the glioma to determine whether the pharmacokinetic model of Extended Tofts Linear could operate reproduceably.Materials and Methods: Nineteen cases of gliomas (seven with low-grade, twelve with high-grade) were enrolled. All of the patients underwent DCE-MRI before operation. The pharmacokinetic model of Extended Tofts Linear was used to calculate the datas, the tissue enhancement-time curve and pharmacokinetic parameters (Ktrans, Ve and Vp) of the lesion, solid components were obtained. Ktrans value, Ve value and Vp value were compared to judge whether there were significant differences between the low-grade glioma and the high-grade glioma of the two groups (survey one and survey two), and whether the pharmacokinetic model of Extended Tofts Linear could operate reproduceably.Results: The values of Ktrans, Ve and Vp in high-grade glioma were significantly higher than the low grade glioma in both groups (survey one and survey two), (P<0.05); The intraclass correlation coefficient (ICC) values of Ktrans, Ve and Vp were 0.93, 0.809, 0.592, separately> 0.4.Conclusion: The reproducibility of the DCE-MRI Extended Tofts Linear is good.
[Keywords] Hemodynamics；Magnetic resonance imaging；Dynamic enhancement；Brain；Glioma

JIA Long-wei Department of Radiology, The Afflilated Hospital of Qingdao University, Qingdao 266000, China

NIU Lei Department of Radiology, The Afflilated Hospital of Qingdao University, Qingdao 266000, China

MA Wen-shuai Department of Radiology, The Afflilated Hospital of Qingdao University, Qingdao 266000, China

LIU Xue-jun Department of Radiology, The Afflilated Hospital of Qingdao University, Qingdao 266000, China

FENG Wei-hua Department of Radiology, The Afflilated Hospital of Qingdao University, Qingdao 266000, China

SUI Qing-lan* Department of Radiology, The Afflilated Hospital of Qingdao University, Qingdao 266000, China

*Corresponding author: Sui QL, E-mail: suiql@163.com

Conflicts of interest   None.

Received  2015-06-01
Accepted  2015-07-08
DOI: 10.3969/j.issn.1674-8034.2015.08.003
DOI:10.3969/j.issn.1674-8034.2015.08.003.

[1]
白雪东，孙夕林，王丹．动态对比增强MRI在鉴别胶质瘤复发及放射性脑损伤中的应用．磁共振成像, 2014, 5(1): 1-6.
[2]
梁长虹．磁共振对比剂临床应用及进展．磁共振成像, 2014, 5(S1): 37-42.
[3]
宋媛，丁爽，贾文霄. DCE-MRI评价肿瘤血管生成的实验研究．放射学实践, 2014, 6(29): 640-643.
[4]
张薇，张龙江，黄伟．动态对比增强MRI的基本原理及其在肝脏病变的应用．国际医学放射学杂志, 2014,37(1): 41-45.
[5]
史红媛，孟庆欣．动态增强磁共振成像评价肿瘤血管新生．临床放射学杂志, 2011, 30(10): 1553-1556.
[6]
黄杰，李晓光，康厚艺，等. DSC-MRI和DCE-MRI定量分析在脑胶质瘤分级诊断中的应用．第三军医大学学报, 2015, 37(7): 672-677.
[7]
范兵，杜华睿，王霄英. MRI动态增强扫描定量参数对脑胶质瘤分级诊断价值的研究．放射学实践, 2014, 29(8): 893-895.
[8]
贾中正，张军，汤伟军. DCE-MRI评估脑胶质瘤微血管的通透性.中国医学计算机成像杂志, 2013, 19(4): 293-297.
[9]
张帆，常双会．动态增强磁共振成像与肿瘤新生血管．医学研究生学报, 2010, 23(9): 977-980.
[10]
杜学松，刘恒．动态对比增强MRI评价大鼠C6胶质瘤肿瘤边缘新生血管的实验研究．中国医学影像学杂志, 2015, 23(2): 81-86.
[11]
朱志军. MRI动态增强定量分析宫颈鳞癌微血管通透性价值的研究．中国CT和MRI杂志, 2015, 13(3):71-73.
[12]
赵京龙，张贵祥．动态增强MR成像在肿瘤血管生成功能成像中的应用．中国医学影像技术, 2004, 20(8): 1293-1295.
[13]
戴曰梅．核磁共振技术在生命科学领域的应用．兵工自动化, 2013, 32(4): 84-96.
[14]
Wetzel SG, Cha S, Law M, et al. Preoperative assessment of intracranial tumors with perfusion MR and a volumetric interpolated examination:a comparative study with DSA. AJNR Am J Nearoradiol, 2002, 23(10): 1767-1774.
[15]
刘鹏飞，那婧，王晓睿，等．MR灌注成像在鉴别脑胶质瘤放疗后坏死与肿瘤复发中的应用.临床放射学杂志, 2007, 26(11): 1080-1083.

PREV Dynamic contrast-enhanced MRI in the differential diagnosis of high grade glioma, low grade glioma and meningioma
NEXT Microvascular permeability changes in ischemic stroke and prediction of hemorrhagic transformation
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn