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• DCE-MRI Quantitative Technique Subject •
Microvascular permeability changes in ischemic stroke and prediction of hemorrhagic transformation
XU Peng-jun  SUN Gang  JIANG Qing-jun  LIU Kai  LI Li  YANG Zhen 

DOI:10.3969/j.issn.1674-8034.2015.08.004.


[Abstract] Objective: To evaluate the permeability changes in ischemic infarction in patients of acute stage and subacute stage and to predict the post-infarction hemorrhagic transformation.Materials and Methods: The data of 43 patients (10 acute stage and 33 subacute stage) who had routine MRI and DCE-MRI performed were retrospectively analyzed. Volume transitional co-efficiency (Ktrans) was measured with pharmacokinetic model. Statistical analysis of Ktrans was performed in the following different groups: infarcted tissue and contralateral normal tissue; hemorrhagic group and non-hemorrhagic group. The correlation of enhancement of different stages was analyzed by Fisher's test.Results: The Ktrans values of infarcted areas dramatically increased compared to those in the conterlateral’s in all cases (P<0.05). Subsequent hemorrhage was found in all 10 cases of acute stage and 15 cases of subacute stage while not found in the rest 18 cases, which was statistically different with Fisher's test (P<0.05). Ktrans values of cases with HT of acute stage were significantly higher than those with or without HT in subacute stage respectively (P<0.05). However, there was no statistical difference in Ktrans values between HT group and non-HT group in subacute stage.Conclusion: The specificity was better in early parenchymal enhancement in predicting HT and the permeability was higher compared to later periods. Early parenchymal enhancement and subsequent HT is likely associated with injury of early capillary endothelial cells of tight dense connections and basement membranes. Parenchymal enhancement in later period and HT is likely associated with establishment of collateral circulation. DCE-MRI could quantitatively evaluate osmotic quantity. It is of great help for further research on HT category.
[Keywords] Hemorrhagic transformation；Microvessels；Blood-brain barrier；Brain infarction；Magnetic resonance imaging

XU Peng-jun Department of Image, Jinan Military Hospital, Jinan 250031, China

SUN Gang* Department of Image, Jinan Military Hospital, Jinan 250031, China

JIANG Qing-jun Department of Image, Jinan Military Hospital, Jinan 250031, China

LIU Kai Department of Image, Jinan Military Hospital, Jinan 250031, China

LI Li Department of Image, Jinan Military Hospital, Jinan 250031, China

YANG Zhen Department of Image, Jinan Military Hospital, Jinan 250031, China

*Corresponding author: Sun G, E-mail: cjr.sungang@vip.163.com

Conflicts of interest   None.

Received  2015-05-05
Accepted  2015-06-04
DOI: 10.3969/j.issn.1674-8034.2015.08.004
DOI:10.3969/j.issn.1674-8034.2015.08.004.

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