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• DCE-MRI Quantitative Technique Subject •
The value of DCE-MRI quantitative permeability parameter combined with ADC in differential diagnosis of benign and malignant lung lesions
WANG Zhen  QIU Xiao-ming  XU Xiao  LUO Li  LU Fen  JIANG Lan  WANG Hong 

DOI:10.3969/j.issn.1674-8034.2015.08.006.


[Abstract] Objective: To investigate the application value of quantitative assessment of pulmonary benign and malignant lesions by kinetic parameters of DCE-MRI imaging combined ADC.Materials and Methods: A total of 49 patients with pulmonary lesions (29 malignant lesions, 20 benign lesions) underwent CT contrast enhanced scanning, routine MR scanning, diffusion-weighted imaging MRI (DWI-MRI), and dynamic enhanced MRI. MRI dynamic enhanced scan with 3D rapid volumetric scanning technology. The ADC values of the lesions were calculated by MRI post-processing workstation, and the kinetic parameters such as Ktrans, Kep et al were calculated by the Omni-Kinetics software.Results: DCE-MRI and DWI-MRI technique for the differential diagnosis of benign and malignant nodules of lung nodules accuracy was 93.9%, ADC value combined with CT in the differential diagnosis of lung nodules accuracy was 85.7%, CT in the differential diagnosis of lung nodules accuracy was 75.5%, the accuracy of DCE-MRI combined with DWI-MRI for differentiating benign and malignant pulmonary nodules was significantly different from CT (P<0.05).Conclusion: DCE-MRI hemodynamic parameters such as Ktrans and Kep combined with ADC values of pulmonary benign and malignant lesions were higher than that of CT, and can be used as a quantitative method of differential diagnosis. It should be widely used in clinical work.
[Keywords] Lung；Lung neoplasms；Magnetic resonance imaging；Dynamic contrast enhanced；Diffusion weighted imaging

WANG Zhen Department of radiology, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University, Hubei Key Laboratory of Kidney Disease Pathogenesis and Intervention, Huangshi City 435000, Hubei Province, China

QIU Xiao-ming Department of radiology, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University, Hubei Key Laboratory of Kidney Disease Pathogenesis and Intervention, Huangshi City 435000, Hubei Province, China

XU Xiao GE healthcare China, Shanghai 201203, China

LUO Li Department of radiology, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University, Hubei Key Laboratory of Kidney Disease Pathogenesis and Intervention, Huangshi City 435000, Hubei Province, China

LU Fen Department of radiology, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University, Hubei Key Laboratory of Kidney Disease Pathogenesis and Intervention, Huangshi City 435000, Hubei Province, China

JIANG Lan Department of chest tumor internal medicine, School district of Pu’ai, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University, Huangshi City 435000, Hubei Province, China

WANG Hong* Department of radiology, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University, Hubei Key Laboratory of Kidney Disease Pathogenesis and Intervention, Huangshi City 435000, Hubei Province, China

*Correspondence to: Wang H, E-mail: 1163214711@qq.com

Conflicts of interest   None.

Received  2015-05-31
Accepted  2015-06-26
DOI: 10.3969/j.issn.1674-8034.2015.08.006
DOI:10.3969/j.issn.1674-8034.2015.08.006.

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