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• DCE-MRI Quantitative Technique Subject •
Correlation of contrast-enhanced dynamic MRI imaging semi-quantitative parameters with tumor tissue hypoxia and intravascular generate
ZHEN Jun-ping  WEI Xiao-chun  WANG Chen  LI Li-zhi  XU Yi  YANG Yu  FAN Peng  NIE Xiao 

DOI:10.3969/j.issn.1674-8034.2015.08.011.


[Abstract] Objective: To investigate the correlation between various internal parameters of dynamic contrast-enhanced MR and the immunohistochemistry factor expression of revelevant site by biopsy.Materials and Methods: Thirty cases of newly diagnosed patients with osteosarcoma were choosen. All cases underwent dynamic contrast-enhanced MR scanning after injecting gadodiamide through the cubital vein. The regional enhancement curve and the characteristic parameters of the tumor were obtained. At the same time, we punctured the related region and measured the HIF-1α, MVD and VEGF levels of the tissue biopsy site. The enhanced parameters and immunohistochemical factors were compared and studied.Results: The slope and Smax, SImax of the biopsy site was positively correlated with HIF-1α expression (γ were respectively 0.894, 0.832 and 0.681, P<0.05), and with the MVD (γ were respectively 0.629, 0.739 and 0.663, P<0.05). The slope and Smax, SImax of the biopsy site and VEGF expression was positively correlated (γ were respectively 0.876, 0.829 and 0.627, P<0.05); Even more, T1 onset, TTP was negatively correlated with HIF-1α expression (γ were-0.692, -0.667, P<0.05 ), and with MVD (γ were-0.574, -0.835, P<0.05).T1 onset, TTP and VEGF expression was negatively correlated (γ were-0.907, -0.830, P<0.05).Conclusion: MRI biopsy site osteosarcoma dynamic enhancement parameters are statistically correlated with the expression of three factors and significantly correlated with tissue hypoxia factor. Dynamic contrast-enhanced scans can provide a basis for the detection of hypoxia and angiogenesis in osteosarcoma tissue indirectly.
[Keywords] Osteosarcoma；Magnetic resonance imaging；Hypoxia-inducible factor 1；Vascular endothelial growth factors；Microvessel density

ZHEN Jun-ping Department of Radiology, The second hospital of Shanxi Medical University, Taiyuan 030001, China

WEI Xiao-chun* Department of Orthopedics, The second hospital of Shanxi Medical University, Taiyuan 030001, China

WANG Chen Department of Pathology, The second hospital of Shanxi Medical University, Taiyuan 030001, China

LI Li-zhi Department of Radiology, The second hospital of Shanxi Medical University, Taiyuan 030001, China

XU Yi Department of Radiology, The second hospital of Shanxi Medical University, Taiyuan 030001, China

YANG Yu Department of Radiology, The second hospital of Shanxi Medical University, Taiyuan 030001, China

FAN Peng Department of Radiology, The second hospital of Shanxi Medical University, Taiyuan 030001, China

NIE Xiao Department of Radiology, The second hospital of Shanxi Medical University, Taiyuan 030001, China

*Corresponding author: Wei XC, E-mail: weixiaochun11@126.com

Conflicts of interest   None.

Received  2015-05-14
Accepted  2015-07-17
DOI: 10.3969/j.issn.1674-8034.2015.08.011
DOI:10.3969/j.issn.1674-8034.2015.08.011.

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