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• Clinical Article •
A study on the best fitting model for diffusion-weighted magnetic resonance imaging of normal prostate tissue at different b-values
ZHI De-bo  QIU Ben-sheng 

DOI:10.3969/j.issn.1674-8034.2015.08.015.


[Abstract] Objective: To compare the fitting behavior of biexponential diffusion model and diffusion kurtosis model (DKI) on diffusion-weighted imaging (DWI) of healthy prostate at different b-values at 1.5 T.Materials and Methods: T2-weighted imaging and DWI of prostate was performed on 11 healthy man with 31 b-values ranging from 0 to 3000 s/mm2. The DWI signals were fitted into two diffusion models. The continuous b-values with smaller deviation between the signal intensities of fitted curves of one model and the acquired original data can be combined into one section. The best fitting model could be selected for the b-values sections.Results: The adjusted R2 of the full b-values for biexponential diffusion model was bigger than that for DKI. The RMSE of DKI was smaller than biexponential model with b-values from 500 to 1000 s/mm2, and the RMSE of biexponential diffusion model was smaller than DKI with b-values ranging from 0 to 500 s/mm2 and from 1000 to 3000 s/mm2.Conclusion: For DWI of prostate, biexponential diffusion model and DKI behaviors diversely on the goodness of fitting at different b-values. The different b-values sections can be fitted best with different diffusion models. It may potentially provide more help for clinical diagnosis when combining the biexponential diffusion model and DKI.
[Keywords] Biexponential diffusion model；Diffusion kurtosis model；Prostate；Diffusion magnetic resonance imaging；Magnetic resonance imaging

ZHI De-bo Center for Biomedical Engineering, University of Science and Technology of China, Hefei 230026, China

QIU Ben-sheng* Center for Biomedical Engineering, University of Science and Technology of China, Hefei 230026, China

*Corresponding author: Qiu BS, E-mail: bqiu@ustc.edu.cn

Conflicts of interest   None.

Received  2015-04-29
Accepted  2015-06-10
DOI: 10.3969/j.issn.1674-8034.2015.08.015
DOI:10.3969/j.issn.1674-8034.2015.08.015.

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