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• Technology Article •
Study of region-of-interest choosing in measuring brain iron content by susceptibility weighted imaging
CHENG Yu  YANG Li-xia  ZHU Yong  HUANG Zi-li  XU Yong-hua 

DOI:10.3969/j.issn.1674-8034.2015.08.016.


[Abstract] Objective: To explore the influence of selecting different region of interest (the whole globus pallidus or a local mineral deposition area) on evaluating the iron content when mineral deposited abnormally in the globus pallidus. The present study might provide a convenient approach to choose the appropriate ROI and to measure the brain iron.Materials and Methods: There were 94 healthy volunteers underwent the routine MRI and SWI scan, and group A had 10 cases with abnormal mineral deposit in the region of globus pallidus, while another 10 cases with normal mineral deposition were group B. Group A was then sub-divided into group A1 or group A2 based on defining the region of the whole globus pallidus (A1) or the region of the only abnormal mineral deposition area as ROI, respectively. Pearson correlation analysis was applied to analyze the relationship between the different ROI on iron measurement and the abnormal mineral depositing content in the region of globus pallidus.Results: The correlation r value between the group A1 and group A2 was 0.827 (P<0.05), which showed that the value of mineral depositing content was remarkably consistent between the two different ROIs measurement (ROI with whole globus pallidusor the local abnormal mineral deposition area). The correlation of r value between group B and group A1, or between group A2 was 0.183 (P>0.05) and 0.344 (P>0.05), respectively. The difference of the signal intensity in globus pallidus was significant between the cases with and without abnormal mineral deposition.Conclusion: We both choose the whole globus pallidus and the local abnormal mineral depositing area as ROI in analyzing the mineral deposition by SWI. Our results showed that these two different ROIs we selected had little influence on brain iron measurements. Therefore we conclude that taking the whole globus pallidus as ROI to measure brain iron content in the globus pallidus by SWI is reliable and much more convenient in comparison with the ROI drawn around the local abnormal mineral depositing area.
[Keywords] Susceptibility weighted imaging；Brain；Iron contents；Region of interest

CHENG Yu Shanghai Clinical Center, Chinese Academy of Sciences/Xuhui Central Hospital, Shanghai 200031, China; School of Life Sciences, Shanghai University, Shanghai 200444, China

YANG Li-xia* Shanghai Clinical Center, Chinese Academy of Sciences/Xuhui Central Hospital, Shanghai 200031, China

ZHU Yong Shanghai Clinical Center, Chinese Academy of Sciences/Xuhui Central Hospital, Shanghai 200031, China

HUANG Zi-li Shanghai Clinical Center, Chinese Academy of Sciences/Xuhui Central Hospital, Shanghai 200031, China

XU Yong-hua Shanghai Clinical Center, Chinese Academy of Sciences/Xuhui Central Hospital, Shanghai 200031, China

*Correspondence to: Yang LX, E-mail: lxyang@scrc.ac.cn

Conflicts of interest   None.

Received  2015-06-08
Accepted  2015-06-30
DOI: 10.3969/j.issn.1674-8034.2015.08.016
DOI:10.3969/j.issn.1674-8034.2015.08.016.

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