Share：
Share this content in WeChat
X
[Chinese][PDF]68897
• Clinical Article •
Correlation between susceptibility weighted imaging and pathological grade of clear cell renal cell carcinom
XU Shao-qi  XING Wei  CHEN Jie  SUN Jun  XING Shi-jun 

DOI:10.3969/j.issn.1674-8034.2015.09.006.


[Abstract] Objective: To evaluate the feasibility of SWI in grading clear cell renal cell carcinoma (CRCC) and compare the ability of SWI and necrosis for grading CRCCs.Materials and Methods: Retrospective reviews of 35 patients with pathologically-proven CRCCs were performed. All patients underwent both conventional MRI and SWI examinations. The morphologies of the intratumoral susceptibility signal intensities (ITSS) were classified into hemorrhage and microvessels. The differences of ITSSs and intratumoral necrosis between low- and high-grade CRCCs were assessed. The diagnostic values of ITSSs and necrosis in differentiating low- from high-grade CRCCs were compared.Results: ITSSs were seen in 31 of 35 patients. No ITSSs were seen in 4 patients with low-grade CRCCs. Mean scores of ITSSs were significantly lower in low-grade CRCCs (1.24±0.72) than that in the high-grade CRCCs (2.70±0.48) (P<0.01). No significant necrosis was seen in 10 patients with low-grade CRCCs. There was a significant difference of the presence of intratumoral necrosis between low- and high-grade CRCCs (P<0.05). Sensitivity, specificity, positive (PPV) and negative predictive values (NPV) were for ITSSs: 70.0%, 100%, 100%, and 89.3%, respectively; for necrosis: 100%, 40.0%, 40.0% and 100%.Conclusions: SWI can evaluate ITSSs and can be an alternative to grade CRCCs preoperatively.
[Keywords] Adenocarcinoma, clear cell；Renal cell carcinoma；Magnetic resonance imaging；Susceptibility weighted imaging；Pathology

XU Shao-qi Department of Radioglogy, Wujin Traditional Medicine Hospital, Changzhou 213161, China

XING Wei* Department of Radioglogy, Changzhou First People's Hospital, Changzhou 213003, China

CHEN Jie Department of Radioglogy, Changzhou First People's Hospital, Changzhou 213003, China

SUN Jun Department of Radioglogy, Changzhou First People's Hospital, Changzhou 213003, China

XING Shi-jun Department of Radioglogy, Changzhou First People's Hospital, Changzhou 213003, China

*Correspondence to: Xing W, E-mail: suzhxingwei@126.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of the Major Program of the Health Bureau of Changzhou
Received  2015-05-18
Accepted  2015-07-29
DOI: 10.3969/j.issn.1674-8034.2015.09.006
DOI:10.3969/j.issn.1674-8034.2015.09.006.

[1]
吴裕强，林祺，兰玉华,等.胶质母细胞瘤多模式MRI表现及其病理组织学基础.磁共振成像, 2013, 4(3): 196-200.
[2]
王绍娟，王利伟，黄海青,等.磁敏感成像序列在脑微出血诊断中的价值.磁共振成像, 2013, 4(5): 335-338.
[3]
Park MJ, Kim HS, Jahng GH, et al. Semiquantitative assessment of intratumoral susceptibility signals using non-contrast-enhanced high-field high-resolution susceptibility-weighted imaging in patients with gliomas: comparison with MR perfusion imaging. AJNR Am J Neuroradiol, 2009, 30(7): 1402-1408.
[4]
Hori M, Mori H, Aoki S, et al. Three-dimensional susceptibility-weighted imaging at 3 T using various image analysis methods in the estimation of grading intracranial gliomas. Magn Reson Imaging, 2010, 28(4): 594-598.
[5]
Xing W, He X, Kassir MA, et al. Evaluating hemorrhage in renal cell carcinoma using susceptibility weighted imaging. PLoS One, 2013, 8(2): e57691.
[6]
Lam JS, Klatte T, Breda A. Staging of renal cell carcinoma: current concepts. Indian J Urol, 2009, 25(4): 446-454.
[7]
Denton MD, Magee CC, Ovuworie C, et al. Prevalence of renal cell carcinoma in patients with ESRD pre-transplantation: a pathologic analysis. Kidney Int, 2002, 61(6): 2201-2209.
[8]
Stiles KP, Moffatt MJ, Agodoa LY, et al. Renal cell carcinoma as a cause of end-stage renal disease in the United States: patient characteristics and survival. Kidney Int, 2003, 64(1): 247-253.
[9]
Gudbjartsson T, Hardarson S, Petursdottir V, et al. Histological subtyping and nuclear grading of renal cell carcinoma and their implications for survival: a retrospective nation-wide study of 629 patients. Eur Urol, 2005, 48 (4): 593-600.
[10]
Li XS, Yao L, Gong K, et al. Growth pattern of renal cell carcinoma (RCC) in patients with delayed surgical intervention. J Cancer Res Clin Oncol, 2012, 138 (2): 269-274.
[11]
陈月洁，黄砚玲，王永峰,等.磁敏感加权成像显示出血对脑胶质瘤分级评估的价值.中国医学影像技术, 2010, 26(2): 247-249.
[12]
MacLennan GT, Bostwick DG. Microvessel density in renal cell carcinoma: lack of prognostic significance. Urology, 1995, 46(1): 27-30.
[13]
Nativ O, Sabo E, Reiss A, et al. Clinical significance of tumor angiogenesis in patients with localized renal cell carcinoma. Urology, 1998, 51(5): 693-696.
[14]
Kinouchi T, Mano M, Matsuoka I, et al. Immature tumor angiogenesis in high-grade and high-stage renal cell carcinoma. Urology, 2003, 62(4): 765-770.
[15]
Minervini A, Di Cristofano C, Gacci M, et al. Prognostic role of histological necrosis for nonmetastatic clear cell renal cell carcinoma: correlation with pathological features and molecular markers. J Urol, 2008, 180(4): 1284-1289.
[16]
Pedrosa I, Chou MT, Ngo L, et al. MR classification of renal masses with pathologic correlation. Eur Radiol, 2008, 18(2): 365-375.

PREV The MRI diagnosis and clinical study of intraspinal epidermoid cyst
NEXT Clinical value of apparent diffusion coefficient and quantitative parameters of MR dynamic enhancement of rectal cancer
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn