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• Clinical Article •
Clinical value of apparent diffusion coefficient and quantitative parameters of MR dynamic enhancement of rectal cancer
CHEN Jin-yin  LIN Qi  TANG Lang-lang  HE Yong-hong  ZHAN Ze-juan 

DOI:10.3969/j.issn.1674-8034.2015.09.007.


[Abstract] Objective: To study the clinical value of diffusion weighted imaging (ADC) and MR dynamic enhanced quantitative parameters of rectal cancer.Materials and Methods: Forty-seven patients of rectal cancer and 16 healthy volunteers underwent multiple b value diffusion weighted imaging (b values respectively 0, 800 s/mm2) and MR dynamic enhanced scanning (adopting the technology of LAVA ISO). (1) ADC values were measured, ADC map was obtained at b 800 s/mm2, three points of interest were measured on the lesions, and ADCmean was the average value. (2) Dynamic enhanced datas were inputted to workstation, and the homodynamic parameters, such as Ktrans, Ve and Kep, were obtained by the dynamic model software. The comparison of the two sample by t test. The Pearson analysis of correlation. The significant threshold was set as P<0. 05.Results: ADCmean, Ktrans and Kep mean of the tumor group were respectively 0.8835×10-3 mm2/s and 2.6680 min-1, 4.7089 min-1, the healthy group respectively 1.34×10-3 mm2/s, 1.548 min-1, and 2.39/min. It was respectively statistically significant in rectal cancer group and healthy group (P values<0.01). And Pearson correlation was not statistically significant (P values>0.05).Conclusions: DWI ADCmean and dynamic enhanced quantitative parameters Ktrans and Kep can effectively distinguish tumor or normal rectal tissue quantitatively, and can be the biomarkers of the rectal cancer in the imaging.
[Keywords] Rectal neoplasms；Diffusion weighted imaging；Magnetic resonance imaging；Image enhancement

CHEN Jin-yin Department of Radiology, the First Hospital of Longyan of Fujian Medical University, Longyan 364000, China

LIN Qi* Department of Radiology, the First Hospital of Longyan of Fujian Medical University, Longyan 364000, China

TANG Lang-lang Department of Radiology, the First Hospital of Longyan of Fujian Medical University, Longyan 364000, China

HE Yong-hong Department of Radiology, the First Hospital of Longyan of Fujian Medical University, Longyan 364000, China

ZHAN Ze-juan Department of Radiology, the First Hospital of Longyan of Fujian Medical University, Longyan 364000, China

*Correspondence to: Lin Q, E-mail: 2624403530@qq.com

Conflicts of interest   None.

Received  2015-07-16
Accepted  2015-08-16
DOI: 10.3969/j.issn.1674-8034.2015.09.007
DOI:10.3969/j.issn.1674-8034.2015.09.007.

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