Share：
Share this content in WeChat
X
[Chinese][PDF]82272
• Clinical Article •
Clinical value of apparent diffusion coefficient and quantitative parameters of MR dynamic enhancement of rectal cancer
CHEN Jin-yin  LIN Qi  TANG Lang-lang  HE Yong-hong  ZHAN Ze-juan 

DOI:10.3969/j.issn.1674-8034.2015.09.007.


[Abstract] Objective: To study the clinical value of diffusion weighted imaging (ADC) and MR dynamic enhanced quantitative parameters of rectal cancer.Materials and Methods: Forty-seven patients of rectal cancer and 16 healthy volunteers underwent multiple b value diffusion weighted imaging (b values respectively 0, 800 s/mm2) and MR dynamic enhanced scanning (adopting the technology of LAVA ISO). (1) ADC values were measured, ADC map was obtained at b 800 s/mm2, three points of interest were measured on the lesions, and ADCmean was the average value. (2) Dynamic enhanced datas were inputted to workstation, and the homodynamic parameters, such as Ktrans, Ve and Kep, were obtained by the dynamic model software. The comparison of the two sample by t test. The Pearson analysis of correlation. The significant threshold was set as P<0. 05.Results: ADCmean, Ktrans and Kep mean of the tumor group were respectively 0.8835×10-3 mm2/s and 2.6680 min-1, 4.7089 min-1, the healthy group respectively 1.34×10-3 mm2/s, 1.548 min-1, and 2.39/min. It was respectively statistically significant in rectal cancer group and healthy group (P values<0.01). And Pearson correlation was not statistically significant (P values>0.05).Conclusions: DWI ADCmean and dynamic enhanced quantitative parameters Ktrans and Kep can effectively distinguish tumor or normal rectal tissue quantitatively, and can be the biomarkers of the rectal cancer in the imaging.
[Keywords] Rectal neoplasms；Diffusion weighted imaging；Magnetic resonance imaging；Image enhancement

CHEN Jin-yin Department of Radiology, the First Hospital of Longyan of Fujian Medical University, Longyan 364000, China

LIN Qi* Department of Radiology, the First Hospital of Longyan of Fujian Medical University, Longyan 364000, China

TANG Lang-lang Department of Radiology, the First Hospital of Longyan of Fujian Medical University, Longyan 364000, China

HE Yong-hong Department of Radiology, the First Hospital of Longyan of Fujian Medical University, Longyan 364000, China

ZHAN Ze-juan Department of Radiology, the First Hospital of Longyan of Fujian Medical University, Longyan 364000, China

*Correspondence to: Lin Q, E-mail: 2624403530@qq.com

Conflicts of interest   None.

Received  2015-07-16
Accepted  2015-08-16
DOI: 10.3969/j.issn.1674-8034.2015.09.007
DOI:10.3969/j.issn.1674-8034.2015.09.007.

[1]
Tofts PS, Brix G, Buckley DL, et al. Estimating kinetic parameters from dynamic contrast-enhanced T1-weighted MRI of a diffusible tracer: standsrdized quantities and synbols. J Magn Reson Imaging, 1999, 10(3): 223-232.
[2]
肖晓娟，余深平，李子平. MR灌注成像在结直肠癌中的应用现状.国际医学放射学杂志, 2015, 38(2): 138-142.
[3]
Gu J, Kong PL, Wang S, et al. Dynamic contrast-enhanced MRI of primary rectal cancer:quantitative correlation with positron emission tomography/computed tomography. J Magn Reson Imaging, 2011, 33(2): 340-347.
[4]
谢宗源，徐香玖，黄刚,等.直肠癌DCE-MRI参数与病理特征的相关性研究.磁共振成像, 2015, 6(4): 289-293.
[5]
Lim JS, Kim D, Back SE, et al. Perfusion MRI for the prediction of treatment response after preoperative chemoradiotherapy in localy advanced rectal cancer. Eur Radiol, 2012, 22(8): 1693-1700.
[6]
Gollub MJ, Gultekin DH, Akin O, et al. Dynamic contrast enhanced-MRI for the detection of pathological complete response to neoadjuvant chemotherapy for locally advanced rectal cancer. Eur Radiol, 2012, 22(4):821-831.
[7]
Yao WW, Zhang H, Ding B, et al. Rectal cancer: 3D dynamic contrast-enhanced MRI:correlation with microvascular density and clinicopathological features. Radiol Med, 2011,116(3): 366-376.
[8]
康英杰，张皓.磁共振弥散加权成像在直肠癌检查中的价值.磁共振成像, 2015, 6(2): 155-160.
[9]
余太慧，杨绮华，章作铨,等.直肠肛门病变的影像学诊断.磁共振成像, 2013, 4(4): 302-308.
[10]
Curvo-Semedo L, Lambregts DM, Maas M, et al. Diffusion-weighted MRI in rectal cancer: apparent diffusion coefficient as a potential noninvasive marker of tumor aggressiveness. J Magn Reson Imaging, 2012, 35(6): 1365-1371.
[11]
亓俊霞，白人驹，于长路,等.磁共振扩散加权成像对直肠癌的显示及其恶性程度评估的初步研究.实用放射学杂志, 2013, 29(3): 400-404.
[12]
Cai G, Xu Y, Zhu J, et al. Diffusion-weighted magnetic resconace imaging for predicting the response of recatal no neoadjuvant concurrent chemoradiation. Word J Gastroenterol, 2013, 19(33): 5520-5527.
[13]
Zhao Q, Liu L, Wang Q. Preoperative diagnosis and staging of rectal cancer using diffusion-weighted and water imaging combined with dynamic contrast-enhanced scanning. Oncol Lett, 2014, 8(6): 2734-2740.
[14]
Ichikawa T, Erturk SM, Motosugi U, et al. High-B-value diffusionweighted MRI in colorectal cancer. Am J Roentgenol, 2006, 187(1): 181-184.

PREV Correlation between susceptibility weighted imaging and pathological grade of clear cell renal cell carcinom
NEXT A study of diffusion tensor imaging characteristics of uterine fibroids with homogeneous hypointense signal on T2WI
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn