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• Clinical Article •
Correlations between MR apparent diffusion coefficient values and prognostic factors of breast invasive ductal carcinoma
ZHANG Yu  MU Xue-tao  ZHONG Xin  DONG Yu-ru  PENG Pai  WANG Hong 

DOI:10.3969/j.issn.1674-8034.2015.09.010.


[Abstract] Objective: To investigate correlations between apparent diffusion coefficient (ADC) values of invasive ductal carcinoma (IDC) and prognostic factors.Materials and Methods: We examined 47 patients by magnetic resonance imaging (MRI) of breast with pathologically confirmed IDC and measured the ADC values of each lesion. The mean ADC values were cross-check analyzed with the prognostic factors.Results: The mean ADC value was (0.957±0.151)×10-3 mm2/s. The mean ADC values of IDC showed inverse correlation with histological grades (r=0.876, P=0.000) and were significantly lower in the cases with large tumor size (t=2.600, P=0.013), axillary lymph nodes metastasis (t=4.123, P=0.000), ER and PR positive expression (t=3.557, P=0.003. t=3.599, P=0.002). HER-2 expression showed no significant correlation with ADC values (t=1.399, P=0.173).Conclusions: The ADC values were correlated with some prognostic factors and might provide valuable information for the prognosis of IDC.
[Keywords] Carcinoma, ductal, breast；Magnetic resonance imaging

ZHANG Yu Department of MRI, the General Hospital of Chinese People’s Armed Police Forces, Beijing 100039, China; Xuzhou Medical College, Xuzhou, Jiangsu 221004, China

MU Xue-tao Department of MRI, the General Hospital of Chinese People’s Armed Police Forces, Beijing 100039, China

ZHONG Xin Department of MRI, the General Hospital of Chinese People’s Armed Police Forces, Beijing 100039, China

DONG Yu-ru Department of MRI, the General Hospital of Chinese People’s Armed Police Forces, Beijing 100039, China

PENG Pai Department of MRI, the General Hospital of Chinese People’s Armed Police Forces, Beijing 100039, China; Xuzhou Medical College, Xuzhou, Jiangsu 221004, China

WANG Hong* Department of MRI, the General Hospital of Chinese People’s Armed Police Forces, Beijing 100039, China

*Correspondence to: Wang H, E-mail: wanghongmri@sina.com

Conflicts of interest   None.

Received  2015-05-19
Accepted  2015-07-29
DOI: 10.3969/j.issn.1674-8034.2015.09.010
DOI:10.3969/j.issn.1674-8034.2015.09.010.

[1]
Caivano R, Villonio A, D' Antuono F, et al. Diffusion weighted imaging and apparent diffusion coefficient in 3 tesla magnetic resonance imaging of breast lesions. Cancer Invest, 2015, 33 (5): 159-64.
[2]
汪海新，应明真，王梅. ER、PR、HER-2、P53在乳腺浸润性导管癌组织中的表达及临床意义.医学研究杂志, 2013, 42(2): 27-31.
[3]
于学娟，柳善刚，陈兆秋,等. 3.0 T磁共振成像表观扩散系数与乳腺浸润性导管癌组织学分级及分子生物学特征的相关性.中华肿瘤杂志, 2014, 36(8): 606-611.
[4]
Choi SY, Chang YW, Park HJ, et al. Correlation of the apparent diffusion coefficiency values on diffusion-weighted imaging with prognostic factors for breast cancer. Br J Radiol, 2012, 85 (1016): e474-479.
[5]
Belli P, Costantini M, Bufi E, et al. Diffusion magnetic resonance imaging in breast cancer characterisation: correlations between the apparent diffusion coefficient and major prognostic factors. Radiol Med, 2015, 120 (3): 268-76.
[6]
王盈盈，常晓丹，付娇慧.乳腺浸润性导管癌3.0TMRI表现与预后因子相关性研究.磁共振成像, 2014, 5(2): 132-137.
[7]
韦苇，谢东，苏丹柯,等.乳腺癌MRI非形态学特征与C-erbB-2表达的相关性研究.磁共振成像, 2014, 5(4): 269-273.
[8]
李斯琴，张晖，韩晓东,等.高场磁共振DWI成像技术对乳腺良恶性病变鉴别诊断的临床价值.现代医用影像学, 2013, 22(6): 464-467, 556.
[9]
陈敏，梁建超，朱红春,等.磁共振扩散加权成像在乳腺良性与恶性病变中表观扩散系数值分布的特征比较研究.实用医学影像杂志, 2014, 15(1): 4-6.
[10]
张卫，苏丹柯，罗宁斌,等. MR扩散加权成像表观扩散系数与乳腺浸润性导管癌病理分级相关性研究.磁共振成像, 2015, 6(2): 131-135.
[11]
刘春玲，何晖，刘再毅,等. ADC值与乳腺浸润性导管癌预后标记物间相关性的探讨.临床放射学杂志, 2014, 33(2): 194-198.
[12]
Tsushima Y, Takahashi-Taketomi A, Endo K. Magnetic resonance(MR) differential diagnosis of breast tumors using apparent diffusion coefficient (ADC) on 1.5-T. J Magn Reson Imaging, 2009, 30(2): 249-255.
[13]
Kuroki-Suzuki S, Kuroki Y, Nasu K, et al. Detecting breast cancer with non-contrast MR imaging: combining diffusion-weighted and STIR imaging. Magn Reson Med Sci, 2007, 6(1): 21-27.
[14]
Park SH, Choi HY, Hahn SY. Correlations between apparent diffusion coefficient values of invasive ductal carcinoma and pathologic factors on diffusion-weighted MRI at 3.0 Tesla. J Magn Reson Imaging, 2015, 41 (1): 175-82.
[15]
Razek AA, Gaballa G, Denewer A, et al. Invasive ductal carcinoma: correlation of apparent diffusion coefficient value with pathological prognostic factors. NMR Biomed, 2010, 23(6): 619-23.
[16]
陈泉桦，刘彪.乳腺MRI多b值下ADC值定量对腋窝淋巴结定性诊断价值及b值优化.磁共振成像, 2014, 5(4): 264-268.
[17]
Kamitani T, Matsuo Y, Yabuuchi H, et al. Correlations between apparent diffusion coefficient values and prognostic factors of breast cancer. Magn Reson Med Sci, 2013, 12 (3): 193-199.
[18]
Jeh SK, Kim SH, Kim HS, et al. Correlation of the apparent diffusion coefficient value and dynamic magnetic resonance imaging findings with prognostic factors in invasive ductal carcinoma. J Magn Reson Imaging, 2011, 33(1): 102-109.

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