Share:
Share this content in WeChat
X
Review
The clinical application and technology progress of high-resolution MRI in carotid intraplaque hemorrhage
YANG Li-xin  DONG Li  YU Wei 

DOI:10.3969/j.issn.1674-8034.2015.09.015.


[Abstract] Stroke is a leading cause of human death and disability, and carotid vulnerable plaque is closely related to the occurrence of stroke, intraplaque hemorrhage is an important feature of vulnerable plaque. Early identification of carotid plaque composition is crucial for the prevention and control of ischemic stroke. High-resolution MRI with advantages of high tissue resolution, non-invasiveness and repeatability, is an effective method to identify carotid vascular morphology and quantify carotid plaque composition. In recent years, MRI technology to diagnosing intraplaque hemorrhage rapidly and accurately is develop continuingly. In this paper, we made an overall review on MRI clinical applications and technical progress incarotid intraplaque hemorrhage.
[Keywords] Carotid Stenosis;Atherosclerosis;Magnetic resonance imaging

YANG Li-xin Department of Radiology, Anzhen Hospital, Capital Medical University, Beijing 100029, China

DONG Li Department of Radiology, Anzhen Hospital, Capital Medical University, Beijing 100029, China

YU Wei Department of Radiology, Anzhen Hospital, Capital Medical University, Beijing 100029, China; The Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Beijing 100029, China

*Correspondence to: Yu W, E-mail: yuwei02@gmail.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of the Program on Health Nonprofit Industry Research Subject No. 201402019 Beijing Health System High-level Health Technical Personnel Training Program No. 2013-2-005 Special Funds of the National Natural Science Foundation of China No. 81071196 Capital Health Development Research Project No. 2011-4003-01
Received  2015-05-05
Accepted  2015-07-19
DOI: 10.3969/j.issn.1674-8034.2015.09.015
DOI:10.3969/j.issn.1674-8034.2015.09.015.

[1]
Ibrahimi P, Jashari F, Nicoll R, et al. Coronary and carotid atherosclerosis: how useful is the imaging? Atherosclerosis, 2013, 231(2): 323-333.
[2]
Redgrave JN, Lovett JK, Gallagher PJ, et al. Histological assessment of 526 symptomatic carotid plaques in relation to the nature and timing of ischemic symptoms: the Oxford plaque study. Circulation, 2006,113(19): 2320-2328.
[3]
Underhill HR, Hatsukami TS, Cai J, et al. A Noninvasive imaging approach to assess plaque severity: the carotid atherosclerosis score. AJNR Am J Neuroradiol, 2010, 31(6): 1068-1075.
[4]
苑纯,赵锡海.易损斑块磁共振成像:共识与挑战.磁共振成像, 2010, 1(6): 429-431.
[5]
Phinikaridou A, Hamilton JA. Application of MRI to detect high-risk therosclerotic plaque. Expet Rev Cardiovasc Ther, 2011, 9(5): 545-550.
[6]
Chu B, Kampschulte A, Ferguson MS, et al. Hemorrhagein theatheroscleroticcarotid plaque: high-resolution MRI study. Stroke, 2004, 35(5): 1079-1084.
[7]
Naghavi M, Libby P, Falk E, et al. From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part I. Circulation, 2003, 108(14): 1664-1672.
[8]
Naghavi M, Libby P, Falk E, et al. From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part Ⅱ. Circulation, 2003, 108(15): 1772-1778.
[9]
Kolodgie FD, Gold HK, Burke AP, et al. Intraplaque hemorrhage and progression of coronary atheroma. N Englj Med, 2003, 349(24): 2316-2325.
[10]
Burke AP, Farb A, Malcom GT, et al. Plaque rupture and sudden death related to exertion in men with coronary artery disease. J Am Med Assoc, 1999, 281(10): 921-926.
[11]
McCarthy MJ, Loftus IM, Thompson MM, et al. Angiogenesis and the atherosclerotic carotid plaque: an association between symptomatology and plaque morphology. J Vasc Surg, 1999, 30(2): 261-268.
[12]
Jeziorska M, Woolley DE. Local neovascularization and cellular composition within vulnerable regions of atherosclerotic plaques of human carotid arteries. J Pathol, 1999, 188(2): 189-196.
[13]
Mofidi R, Crotty TB, McCarthy P, et al. Association between plaque instability, angiogenesis and symptomatic carotid occlusive disease. Br J Surg, 2001, 88(7): 945-950.
[14]
Kockx MM, Cromheeke KM, Knaapen MW, et al. Phagocytosis and macrophage activation associated with hemorrhagic microvessels in human atherosclerosis. Arterioscler Thromb Vasc Biol, 2003, 23(3): 440-446.
[15]
Fleiner M, Kummer M, Mirlacher M, et al. Arterial neovascularization and inflammation in vulnerable patients: early and late signs of symptomatic atherosclerosis. Circulation, 2004, 110(18): 2843-2850.
[16]
Takaya N, Yuan C, Chu BC, et al. Presence of intraplaque hemorrhage stimulates progression of carotid atherosclerotic plaques-A high-resolution magnetic resonance Imaging study. Circulation, 2005, 111(21): 2768-2775.
[17]
Underhill HR, Yuan C, Yarnykh VL, et al. Arterial remodeling in the subclinical carotid artery disease. J Am Coll Cardiol Img, 2009, 2(12): 1381-1389.
[18]
Grimm JM, Schindler A, Freilinger T, et al. Comparison of symptomatic and asymptomatic atherosclerotic carotid plaques using parallel imaging and 3 T black-blood in vivo CMR. J Cardiovasc Magn Reson, 2013, 15: 44-53.
[19]
WallisdeVries BM, vanDam GM, Tio RA, et al. Current imaging modalities to visualize vulnerability within the atherosclerotic carotid plaque. J Vasc Surg, 2008, 48(6): 1620-1629.
[20]
Saam T, Cai J, Ma L, et al. Comparison of symptomatic and asymptomatic atherosclerotic carotid plaque features with in vivo MR imaging. Radiology, 2006, 240(2): 464-472.
[21]
Altaf N, Daniels L, Morgan PS, et al. Detection of intraplaque hemorrhage by magnetic resonance imaging in symptomatic patients with mild to moderate carotid stenosis predicts recurrent neurological events. J Vasc Surg, 2008, 47(2): 337-342.
[22]
Demarco JK, Ota H, Underhill HR, et al. MR carotid plaque imaging and contrast-enhanced MR angiography identifies lesions associated with recent ipsilateral thromboembolic symptoms: an in vivo study at 3 T. AJNR Am J Neuroradiol, 2010, 31(8): 1395-1402.
[23]
Sun J, Underhill HR, Hippe DS, et al. Sustained acceleration in carotid atherosclerotic plaque progression with intraplaque hemorrhage. JACC Cardiovasc Imaging, 2012, 5(8): 798-804.
[24]
张兆琪,董莉,于薇. MRI对易损斑块的临床研究进展.磁共振成像, 2010, 1(6): 422-428.
[25]
Moody AR, Murphy RE, Morgan PS, et al. Characterization of complicated carotid plaque with magnetic resonance direct thrombus imaging in patients with cerebral ischemia. Circulation, 2003, 107(24): 3047-3052.
[26]
Mendes J, Parker DL, Kim SE, et al. Reduced blood flow artifact in intraplaque hemorrhage imaging using CineMPRAGE. Magn Reson Med, 2013, 69(5): 1276-1284.
[27]
Ota H, Yarnykh VL, Ferguson MS, et al. Carotid intraplaque hemorrhage imaging at 3.0-T MR imaging: comparison of the diagnostic performance of three T1-weighted sequences. Radiology, 2010, 254(2): 551-563.
[28]
Bitar R, Moody AR, Leung G, et al. In vivo 3D high-spatial-resolution MR imaging of intraplaque hemorrhage. Radiology, 2008, 249(1): 259-267.
[29]
Wang J, Ferguson MS, Balu N, et al. Improved carotid intraplaque hemorrhage imaging usinga slab-selective phase-sensitive inversion-recovery (SPI) sequence. Magn Reson Med, 2010, 64(5): 1332-1340.
[30]
Wang J, Bornert P, Zhao H, et al. Simultaneous non-contrast angiography and intra plaque hemorrhage (SNAP) imaging for carotid atherosclerotic disease evaluation. Magn Reson Med, 2013, 69(2): 337-345.
[31]
Moody AR, Murphy RE, Morgan PS, et al. Characterization of complicated carotid plaque with magnetic resonance direct thrombus imaging in patients with cerebral ischemia. Circulation, 2003, 107(24): 3047-3052.
[32]
Zhu DC, FergusonMS, DeMarco JK. Anoptimized 3D inversion recovery prepared fast spoiled gradient recalled sequence for carotid plaque hemorrhage imaging at 3.0 T. Magn Reson Imaging, 2008, 26(10): 1360-1366.
[33]
Zhu DC, Vu AT, Ota H, et al. An optimized 3D spoiled gradient recalled echo pulse sequence for hemorrhage assessment using inversion recovery and multiple echoes (3D SHINE) for carotid plaque imaging. Magn Reson Med, 2010, 64(5): 1341-1351.
[34]
Fan Z, Yu W, Xie Y, et al. Multi-contrast atherosclerosis characterization (MATCH) of carotid plaque with a single 5-min scan: technical development and clinical feasibility. J Cardiovasc Magn Reson, 2014, 16: 53.
[35]
梁长虹.磁共振对比剂临床应用及展.磁共振成像, 2014, 5(增刊1): 37-42.
[36]
Sun J, Song Y, Chen H, et al. Adventitial perfusion and intraplaque hemorrhage: a dynamic contrast-enhanced MRI study in the carotid artery. Stroke, 2013, 44(4): 1031-1036.

PREV Technical progress of pituitary adenoma MRI
NEXT Research advancements of single-domain antibody in molecular imaging of prostate cancer
  



Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn