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• Clinical Article •
Magnetic resonance imaging for the diagnosis and prognosis of neonatal cerebral white matter diffuse excessive high signal intensity
BO Ru-ting  Ji Guang-hai  LIU Ling-ling  WU Yu-hua  QIU Yin-ping  YANG Wen-jun  LI Yan  CHEN Zhi-qiang 

DOI:10.3969/j.issn.1674-8034.2015.10.004.


[Abstract] Objective: To explore the value of magnetic resonance imaging (MRI) in the diagnosis and prognosis of neonatal cerebral white matter diffuse excessive high signal intensity (DEHSI).Materials and Methods: To compare and analyze the typical features in MRI, the process of cerebral white matter lesions and the neurodevelopmental outcomes of neonates.Results: Postnatal age, gestational age, head girth had a significantly negative correlation with DEHSI (r=-0.266, -0.303, -0.200, all P<0.05). There was a negative correlation between the grade of DEHSI and the Gesell scores (ADQ, GMDQ, FMDQ, LDQ, PSDQ) of infants at 5 month corrected age (r=-0.423, -0.499, -0.553, -0.317, -0.453, all P<0.05).Conclusion: Extrauterine exposure time could promote the degree of prematurity in infants. In addition, the long time stay in intrauterine, the higher the maturity, and the lower grade of DEHSI. MRI could distinguish the different grades of DEHSI and assess the neurodevelopmental outcomes. The neurodevelopmental outcomes was poor in moderate-sereve DEHSI of infants, which was good in infants with no or mild DEHSI.
[Keywords] Neonate；Diffuse excessive high signal intensity；Leukoencephalopathies；Magnetic resonance imaging

BO Ru-ting Ningxia Medical University clinical medical college, Yinchuan 750004, China

Ji Guang-hai Ningxia Medical University clinical medical college, Yinchuan 750004, China

LIU Ling-ling Ningxia Medical University clinical medical college, Yinchuan 750004, China

WU Yu-hua Department of Neonatology, General hospital of Ningxia Medical University, Yinchuan 750004, China

QIU Yin-ping Department of Neonatology, General hospital of Ningxia Medical University, Yinchuan 750004, China

YANG Wen-jun Key Laboratory of Fertility Maintenance, Ministry of Education, Ningxia Medical University, Yinchuan 750004, China

LI Yan Department of Radiology, General hospital of Ningxia Medical University, Yinchuan 750004, China

CHEN Zhi-qiang* Department of Radiology, General hospital of Ningxia Medical University, Yinchuan 750004, China

*Correspondence to: Chen ZQ, E-mail: zhiqiang_chen99@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of science and technology research project of Ningxia No. W2015 Science and technology research project of Yinchuan No. W2015-4 Key project of Ningxia Medical University No.XM2014
Received  2015-04-23
Accepted  2015-06-26
DOI: 10.3969/j.issn.1674-8034.2015.10.004
DOI:10.3969/j.issn.1674-8034.2015.10.004.

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