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• Clinical Article •
Gd-EOB-DTPA enhanced MR imaging: a study about the delay time of hepatobiliary phase in patients with normal liver function
DING Ding  LU Jian  LI Mei-ling  ZHANG Xue-qin  ZHANG Tao  DU Sheng  XU Xiao-li  JIANG Ji-feng  YANG Xue-fei 

DOI:10.3969/j.issn.1674-8034.2015.10.008.


[Abstract] Objective: To assess whether, in patients with normal liver function, a hepatobiliary delay time of 10 min after Gd-EOB-DTPA injection is sufficient for lesion detection and diagnosis.Materials and Methods: A total of 38 patients with normal liver function who has liver lesion were included in this study, and MRI was performed after intravenous Gd-EOB-DTPA, followed by dynamic contrast phases at 25 s, 60 s, 180 s and hepatobiliary phases at 10 min and 20 min. We’ve measured the signal intensity (SI) of liver and erector spinae muscle, and then calculating liver ratio, muscle ratio, liver-muscle ratio, liver SNR, lesion SNR (hypo- and hyperintense lesions) and CNR (hypo- and hyperintense lesions), recording the time of contrast agent excrete in bile ducts meanwhile. In all, we compared the differences of liver SI and the ability to show lesion’s information between 10 min and 20 min hepatobiliary phases.Results: Following enhancement, liver SI increased significantly up to 10 min, and subsequently stabilized. Differences of liver ratio, muscle ratio and liver-muscle ratio between hepatobiliary phases of 10 min and 20 min were statistically significant(P<0.05). There was no statistical difference of liver SNR between hepatobiliary phases of 10 min and 20 min(P>0.05). Difference of hyperintense lesions SNR between 10 min and 20 min hepatobiliary phases was statistically significant(P<0.05), but hypointense lesions SNR wasn’t (P>0.05). Neither hypo- nor hyperintense lesions CNR has statistical difference between 10 min and 20 min hepatobiliary phases(P>0.05). Besides, biliary contrast agent excretion was first observed after 10 min in 26 patients (68.42%).Conclusion: A hepatobiliary delay time of 10 min after Gd-EOB-DTPA injection is sufficient for lesion detection and diagnosis in patients with normal liver function.
[Keywords] Gd-EOB-DTPA；Magnetic resonance imaging, enhancement；Hepatobiliary phase

DING Ding Department of Radiology, The 3rd Affiliated Hospital of Nantong University, Nantong 226001, China

LU Jian* Department of Radiology, The 3rd Affiliated Hospital of Nantong University, Nantong 226001, China

LI Mei-ling Department of Radiology, The 3rd Affiliated Hospital of Nantong University, Nantong 226001, China

ZHANG Xue-qin Department of Radiology, The 3rd Affiliated Hospital of Nantong University, Nantong 226001, China

ZHANG Tao Department of Radiology, The 3rd Affiliated Hospital of Nantong University, Nantong 226001, China

DU Sheng Department of Radiology, The 3rd Affiliated Hospital of Nantong University, Nantong 226001, China

XU Xiao-li Department of Radiology, The 3rd Affiliated Hospital of Nantong University, Nantong 226001, China

JIANG Ji-feng Department of Radiology, The 3rd Affiliated Hospital of Nantong University, Nantong 226001, China

YANG Xue-fei Department of Radiology, The 3rd Affiliated Hospital of Nantong University, Nantong 226001, China

*Correspondence to: Lu J, E-mail: whg678@sina.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This paper was part of social development project of Nantong Science and Technology bureau No. HS2013011 the preeminent youth fund project of Nantong health department No. WQ2014039
Received  2015-08-25
Accepted  2015-09-20
DOI: 10.3969/j.issn.1674-8034.2015.10.008
DOI:10.3969/j.issn.1674-8034.2015.10.008.

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