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• Clinical Article •
The effect caused by interictal epileptic discharges on mesial temporal lobe epilepsy brain networks
WU Han  ZHANG Zhi-qiang  XU Qiang  ZHANG Qi-rui  CHEN Guang-hui  YANG Fang  SUN Kang-jian  LU Guang-ming 

DOI:10.3969/j.issn.1674-8034.2015.11.001.


[Abstract] Objective: To comprehensively assess the alterations of resting-state brain networks affected by interictal epileptic discharges (IEDs) in mesial temporal lobe epilepsy (mTLE), and to reveal the mechanism of brain function damages caused by IEDs in mTLE.Materials and Methods: Forty-five patients with bilateral mTLE underwent continuous EEG-fMRI during rest. Finally 35 fMRI sessions (left mTLE, n=18) with IEDs and individually paired non-IEDs sessions were acquired. Independent component analysis was used to investigate the alterations in different states of seven resting-state networks including the core network, dorsal attention network, executive control network, anterior and posterior default mode network, auditory network, visual network and sensorimotor network.Results: Paired t-test results showed, compared with non-IEDs state, the anterior cingulum cortex in core network showed increased coherence of brain activity and the auditory network showed decreased activity in both groups of mTLE. Apart from this, superior parietal gyrus in dorsal attention network showed reverse performance when the epileptic focus located in different sides of the brain. While it increased in left mTLE, but decreased in right mTLE. The middle temporal gyrus and post cingulum in posterior default mode network showed increased activity, while the middle frontal gyrus in anterior default mode network showed decreased activity in IEDs state in right mTLE. The middle cingulum in executive control network and middle occipital gyrus in visual network showed increased coherence of brain activity in left mTLE. And the changed mean connectivity strength in visual network of left mTLE and auditory network of right mTLE were positively correlated with the number of IEDs.Conclusions: This study revealed IEDs in mTLE have an extensive impact in the resting-state brain networks, especially for the networks damage involved in higher cognitive functions of the brain. This study was expected to contribute to further understanding of the mechanism of brain functional injury in mTLE.
[Keywords] Epilepsy, temporal lobe；Electroencephalography phase synchronization；Magnetic resonance imaging；Seizures

WU Han Department of Medical Imaging, Nanjing General Hospital of Nanjing Military Command, Nanjing University, Nanjing 210002, China

ZHANG Zhi-qiang Department of Medical Imaging, Nanjing General Hospital of Nanjing Military Command, Nanjing University, Nanjing 210002, China

XU Qiang Department of Medical Imaging, Nanjing General Hospital of Nanjing Military Command, Nanjing University, Nanjing 210002, China

ZHANG Qi-rui Department of Medical Imaging, Nanjing General Hospital of Nanjing Military Command, Nanjing University, Nanjing 210002, China

CHEN Guang-hui Department of Neurology, Nanjing General Hospital of Nanjing Military Command, Nanjing University, Nanjing 210002, China

YANG Fang Department of Neurology, Nanjing General Hospital of Nanjing Military Command, Nanjing University, Nanjing 210002, China

SUN Kang-jian Department of Neurosurgery, Nanjing General Hospital of Nanjing Military Command, Nanjing University, Nanjing 210002, China

LU Guang-ming* Department of Medical Imaging, Nanjing General Hospital of Nanjing Military Command, Nanjing University, Nanjing 210002, China

*Correspondence to: Lu GM, E-mail: cjr.luguangming@vip.163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This article research work obtained the National Natural Sciences Foundation of China project subsidization No. 81271553
Received  2015-07-30
Accepted  2015-09-12
DOI: 10.3969/j.issn.1674-8034.2015.11.001
DOI:10.3969/j.issn.1674-8034.2015.11.001.

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