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• Clinical Article •
Analysis of the characteristics of Virchow-Robin spaces in Alzheimer's disease
ZHANG Xiao-ling  YIN Ping  ZHANG Xiao-hui  LIU Yi  SHI Xiao-qing  LUO Tian-you  LÜ Fa-jin  LI Yong-mei 

DOI:10.3969/j.issn.1674-8034.2015.11.002.


[Abstract] Objective: To study the correlation between Magnetic Resonance Imaging of Virchow-Robin spaces (VRS) and Alzheimer’s disease (AD).Materials and Methods: Seventy AD patients (AD group) and sixty-two normal controls (control group) were detected by brain MRI, and their VRS in the midbrain, basal ganglia, deep insular white matter and centrum semiovale were numbered and measured. The results were compared between the two groups.Results: VRS were observed in multiple brain regions of AD groups, typically in basal ganglia. The discovery rate of VRS in AD group (49.1%, 34/70) was higher than that in control group (24.2%, 15/62), the difference is statistically significant (P<0.05).The number of VRS in AD group [(4.1±2.2)/case] was more than that in control group [(2.4±1.9)/case], the difference is statistically significant (P<0.05).The diameter of VRS in AD group [(2.8±1.2) mm] was larger than that in control group [(1.8±0.5) mm], the difference is statistically significant (P<0.05). Linear regression analysis showed the number, diameter of VRS in control group were both positive correlated with the age (r1=0.802, r2=0.902, all P<0.05).Conclusions: VRS in AD has its own characteristics, should cause the attention of clinical.
[Keywords] Virchow-Robin spaces；Magnetic resonance imaging；Alzheimer disease

ZHANG Xiao-ling Department of Radiology, First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

YIN Ping Department of Radiology, First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

ZHANG Xiao-hui Department of Radiology, First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

LIU Yi Department of Radiology, First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

SHI Xiao-qing Department of Radiology, First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

LUO Tian-you Department of Radiology, First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

LÜ Fa-jin Department of Radiology, First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

LI Yong-mei* Department of Radiology, First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

*Correspondence to: Li YM, E-mail: lymzhang70@aliyun.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  The article is supported by the National Normal Science Foundation of China under grant NO. 81371523 Medicine Scientific key Research Project of Chongqing health bureau grant NO. 2011-1-031 Medicine Scientific key Research Project of chongqing health bureau grant NO. 2012-1-017 supported by National Key Clinical Specialties Construction Program of China N0. 2013-544
Received  2015-09-08
Accepted  2015-10-10
DOI: 10.3969/j.issn.1674-8034.2015.11.002
DOI:10.3969/j.issn.1674-8034.2015.11.002.

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