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• Clinical Article •
Applications of 1H-MRS and clinical relative factors in diagnosis of neonatal cerebral white matter diffuse excessive high signal intensity
BO Ru-ting  Ji Guang-hai  Zheng Yi  LIU Ling-ling  WU Yu-hua  YANG Wen-jun  CHEN Zhi-qiang 

DOI:10.3969/j.issn.1674-8034.2015.11.003.


[Abstract] Objective: Use proton magnetic resonance spectroscopy (1H-MRS) to observe the imaging features in neonatal cerebral white matter diffuse excessive high signal (DEHSI) and explore the evolution of DEHSI and diagnostic value.Materials and Methods: This study included 95 neonates, using MRS for the study of the region of interest in cerebral white matter lesions.Results: Postnatal age, gestational age, and head girth had significantly negative correlation with DEHSI (r=-0.398, r=-0.390, r=-0.269, all P<0.05). Gestational age and postnatal age with the ratios of NAA/Cr (r=0.386, r=0.328, all P<0.05), and NAA/Cho (r=0.432, r=0.367, all P<0.05) were discovered with a clearly positive significant difference and a marked negatively correlated with the values Cho/Cr (r=-0.204, r=-0.211, all P<0.05), and MI/Cr(r=-0.243, r=-0.286, all P<0.05). In addition, the increasing extent of DEHSI was associated with a significant decrease in NAA concentration, NAA/Cr in relation to NAA/Cho (r=-0.320, r=-0.394, r=-0.565, all P<0.05), resulting in an increase in Cho/Cr and MI/Cr (r=0.389, r=0.376, all P<0.05). Compared with control group, Cho/Cr and MI/Cr were significantly elevated, whereas NAA/Cr and NAA/Cho ratios were significantly decreased in infants with mild DEHSI and moderate-sereve DEHSI (all P<0.05).Conclusions: Postnatal age, gestational age, and head girth had negative correlation with DEHSI. Gestational age and postnatal age were related to metabolite levels in neonatal brain. In addition, when it stayed in intrauterine for the long time, and it had the higher maturity, the lower grade of DEHSI, which was resulting in elevating NAA concentrations.
[Keywords] Neonate；Brain；Diffuse excessive high signal intensity；Magnetic resonance spectroscopy

BO Ru-ting Ningxia Medical University, Yinchuan 750004, China

Ji Guang-hai Ningxia Medical University, Yinchuan 750004, China

Zheng Yi Ningxia Medical University, Yinchuan 750004, China

LIU Ling-ling Department of Radiology, General Hospital of Ningxia Medical University, Yinchuan 750004, China

WU Yu-hua Department of Neonatology, General Hospital of Ningxia Medical University, Yinchuan 750004, China

YANG Wen-jun Key Laboratory of Fertility Maintenance, Ministry of Education, Ningxia Medical University, Yinchuan 750004, China

CHEN Zhi-qiang* Department of Radiology, General Hospital of Ningxia Medical University, Yinchuan 750004, China

*Correspondence to: Chen ZQ, E-mail: zhiqiang_chen99@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of the Program of Science and Technology Foundation of Ningxia No. W2015 The work was supported by Yinchuan Science and Technology Key Projects Fund No. W2015-4 The work was supported by Key Project of Ningxia Medical University No. XM2014
Received  2015-08-19
Accepted  2015-10-05
DOI: 10.3969/j.issn.1674-8034.2015.11.003
DOI:10.3969/j.issn.1674-8034.2015.11.003.

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