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• Clinical Article •
1H magnetic resonance spectroscopy study on the short term changes of skeletal muscle after treatment in type 2 diabetes mellitus
SUN Pei-yi  SONG Ying-ru  CHEN Qing-yun 

DOI:10.3969/j.issn.1674-8034.2015.11.007.


[Abstract] Objective: To evaluate the changes of intramyocellular lipid (IMCL) and extramyocellular lipid (EMCL) at the soleus of right leg by 1H magnetic resonance spectroscopy (1H-MRS) after treatment within 4 weeks and correlate to insulin resistance index (HOMA-IR) in incipient non-thin type 2 diabetes.Materials and Methods: Thirty incipience non-thin type 2 diabetes were collected, and divided into insulin with metformin treatment group (n=20), no-drug treatment group (n=10). Healthy volunteers acted as control group (n=10). All groups were underwent 1H-MRS at the soleus of right leg. IMCL and EMCL were evaluated at 0 days, 14 days (2 weeks), and 28 days (4 weeks). HOMA-IR of treatment group was measured corresponding to duration of 1H-MRS scans. Statistical analysis was performed using SPSS 17.0 package. One-way ANOVA or Kruskal-Wallis test were used to analyze the difference of IMCL and EMCL at each group. Pearson correlations were evaluated between IMCL and HOMA-IR in the treatment group.Results: IMCL and HOMA-IR were obviously reduced in drug treatment group at 4 weeks (P=0.008, 0.015). IMCL in treatment group correlated to HOMA-IR positively.Conclusions: IMCL at soleus evaluated by 1H-MRS of non-thin type 2 diabetes was sensitive and quantified to the changes of insulin resistance level during short term treatment.
[Keywords] Magnetic resonance spectroscopy；Muscles；Diabetes mellitus, Type 2；Lipid metabolism disorders

SUN Pei-yi Departent of Radiology, the First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530023, China

SONG Ying-ru* Department of Radiology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China

CHEN Qing-yun Endocrine Department, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China

*Correspondence to: Song YR, E-mail: syrhqq@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  Scientific research project of Guangxi Education Department No. 201010LX034
Received  2015-08-31
Accepted  2015-10-19
DOI: 10.3969/j.issn.1674-8034.2015.11.007
DOI:10.3969/j.issn.1674-8034.2015.11.007.

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