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• Clinical Article •
The reproducibility of IVIM-DWI in normal prostate and age-related analysis
ZHANG Dong  WU Ting  SHI Chang-zheng  LUO Liang-ping 

DOI:10.3969/j.issn.1674-8034.2015.11.010.


[Abstract] Objective: To investigate the reproducibility of the intravoxel incoherent motion diffusion weighted imaging (IVIM-DWI) derived parameters, and analyze the change of the IVIM-DWI derived parameters of normal prostate in different age groups.Materials and Methods: Sixty-six volunteers conformed to the standards were divided into three groups (group A, 15—30 years, 13. Group B, 31—50 years, 25. Group C, ≥51 years, 28) and underwent the scanning of IVIM-DWI with 15 b-factors from 0 to 3000 (0, 25, 50, 75, 100, 150, 200, 400, 600, 800, 1000, 1200, 1500, 2000, 3000 s/mm2) twice with an interval of 30 minutes using 3.0 T MRI device, the biexponential fits were applied to figure out the slow ADC, fast ADC and f values. The reproducibility of every parameters were investigated by the paired t-test. The differences of every parameters in normal prostate between the three age groups were assessed using one-way analysis of variance (ANOVA) and the least significant difference (LSD) t-test.Results: Slow ADC, fast ADC and f values showed good reproducibility in both peripheral zone (PZ) and central gland (CG) of three age groups, except fast ADC in CG of group A (P=0.022). The slow ADC and f values of the prostate peripheral zone and central gland had the upward tendency with age increasing. Slow ADC showed significant difference between group A and B, group A and C, while had no significant difference between group B and C in PZ, and slow ADC showed significant difference between group A and C, group B and C, while had no significant difference between group A and B in CG. Fast ADC in both PZ and CG between three age groups had no significant different. F value show significant difference between three age groups in PZ, while in CG f value show significant difference between group A and C, group B and C, while had no significant difference between group A and B.Conclusions: In general, a good reproducibility of IVIM-DWI derived parameters in normal prostate of three age groups was observed. IVIM-DWI technology reflected the age-related change of prostate tissues in the celluar level, and the derived parameters could set a reliable reference to the quantitative analysis of prostate diseases.
[Keywords] Prostate；Magnetic resonance imaging；Age factors

ZHANG Dong Center of Medical Imaging, the Fist Affiliated Hospital of Jinan University, Guangzhou 510632, China

WU Ting Center of Medical Imaging, the Fist Affiliated Hospital of Jinan University, Guangzhou 510632, China

SHI Chang-zheng Center of Medical Imaging, the Fist Affiliated Hospital of Jinan University, Guangzhou 510632, China

LUO Liang-ping* Center of Medical Imaging, the Fist Affiliated Hospital of Jinan University, Guangzhou 510632, China

*Correspondence to: Luo LP, E-mail: tluolp@jnu.edu.cn

Conflicts of interest   None.

ACKNOWLEDGMENTS  This article was funded by Social development of science and technology plan projects in Guangdong province No. 2013B021800161
Received  2015-08-23
Accepted  2015-09-26
DOI: 10.3969/j.issn.1674-8034.2015.11.010
DOI:10.3969/j.issn.1674-8034.2015.11.010.

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