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• Technical Article •
A research about the development of response inhibition in children and adolescents using fMRI base on Go/NoGo task
ZHANG Hui  WANG Meng-xing  ZHANG Kai-hua  ZHANG Ji-lei  Meng wei-xia  DU Xiao-xia 

DOI:10.3969/j.issn.1674-8034.2015.11.012.


[Abstract] Objective: To investigate the development of motor response inhibition and error processing abilities in children and adolescents using functional magnetic resonance imaging (fMRI) in combination with a Go/NoGo task.Materials and Methods: Forty-two children and adolescents, ranging in age from 8 to 17, took part in this experiment, while behavioral and fMRI data were collected. The data were analyzed using SPM8 and SPSS, and then correlation analysis was done between age and the inferior frontal gyrus, a key area for motor response inhibition.Results: The results showed that reaction time was decreased with age, while accuracy was increased with age during the Go/NoGo task. We investigated that the activation of the inferior frontal gyrus was increased significantly with age in 8—15 year-old subjects during response inhibition. Furthermore, we observed that the activation of the inferior frontal gyrus reached a peak platform in the late adolescence. And the activation of right inferior frontal gyrus was increased significantly with age during error processing.Conclusions: These data suggest that the inferior frontal gyrus plays an important role in motor response inhibition. The inferior frontal gyrus may develop with age in early adolescence, and then reach a peak platform in late adolescence, when it is mature and close to adult level.
[Keywords] Children and adolescents；Response inhibition；Magnetic resonance imaging；Inferior frontal gyrus；Development；Error processing

ZHANG Hui Shanghai Key Laboratory of Magnetic Resonance & Department of Physics, East China Normal University, Shanghai 200062, China

WANG Meng-xing Shanghai Key Laboratory of Magnetic Resonance & Department of Physics, East China Normal University, Shanghai 200062, China

ZHANG Kai-hua Shanghai Key Laboratory of Magnetic Resonance & Department of Physics, East China Normal University, Shanghai 200062, China

ZHANG Ji-lei Shanghai Key Laboratory of Magnetic Resonance & Department of Physics, East China Normal University, Shanghai 200062, China

Meng wei-xia Department of Pediatrics, China Resources & Wisco General Hospital, Wuhan 430080, China

DU Xiao-xia* Shanghai Key Laboratory of Magnetic Resonance & Department of Physics, East China Normal University, Shanghai 200062, China

*Correspondence to: Du XX, E-mail: xxdu@phy.ecnu.edu.cn

Conflicts of interest   None.

ACKNOWLEDGMENTS  This article research work obtained the National Natural Sciences Foundation of China project subsidization No. 81201082 and 81571658
Received  2015-09-11
Accepted  2015-10-16
DOI: 10.3969/j.issn.1674-8034.2015.11.012
DOI:10.3969/j.issn.1674-8034.2015.11.012.

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