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• Overseas Papers •
Principle and application of hyperpolarized magnetic resonance spectroscopy
QI Hai-yun  ZHANG Xiao-lu  XU Ya-fang  WEN Jian-guo  XU Yu-ming  CHENG Jing-liang  Chen Albert P.  Bertelsen Lotte Bonde  Ringgaard Steffen  Laustsen Christoffer  Stødkilde-Jørgensen Hans 

QI Hai-yun , ZHANG Xiao-lu and XU Ya-fang contributed equally to this article DOI:10.3969/j.issn.1674-8034.2015.12.001.


[Abstract] The polarization of nuclear spins can be enhanced above the thermal equilibrium polarization with dynamic nuclear polarization (DNP) to achieve signal-noise ratio improvement of greater than 10,000-fold in magnetic resonance, this technique is denoted "hyperpolarization"(HP). Dissolution DNP is allowed the enhanced sample to be transferred from the polarizer and injected in vivo, providing realtime measurement of perfusion, metabolite transport, and metabolism, which break the constraint of traditional magnetic resonance in detecting cellular metabolism in real time in vivo. The definition and introduction to the DNP technique, hyperpolarized bio-probes and applications, and analysis and interpretation of results from magnetic resonance images/spectroscope in pre-clinical and clinical areas were reviewed.
[Keywords] Hyperpolarization；Dynamic nuclear polarization；Bio-probes；Bio-reactor；Magnetic resonance spectroscopy；Magnetic resonance imaging

QI Hai-yun MR Research Centre, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark

ZHANG Xiao-lu MR Research Centre, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark

XU Ya-fang MR Research Centre, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark

WEN Jian-guo The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052 China

XU Yu-ming The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052 China

CHENG Jing-liang The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052 China

Chen Albert P. GE Healthcare, Toronto Canada

Bertelsen Lotte Bonde MR Research Centre, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark

Ringgaard Steffen MR Research Centre, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark

Laustsen Christoffer MR Research Centre, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark

Stødkilde-Jørgensen Hans* MR Research Centre, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark

*Correspondence to: Hans Stødkilde-Jørgensen, E-mail: hsj@mr.au.dk

Conflicts of interest   None.

Received  2015-09-07
Accepted  2015-11-02
DOI: 10.3969/j.issn.1674-8034.2015.12.001
QI Hai-yun , ZHANG Xiao-lu and XU Ya-fang contributed equally to this article DOI:10.3969/j.issn.1674-8034.2015.12.001.

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